摘要
结核病和寄生虫病均为全球重大的公共卫生问题,世界各地已报道了多个结核菌和寄生虫双重感染以及结核病与寄生虫病误诊的案例,两种疾病之间的关联不容忽视.结核菌不仅可与单一寄生虫发生双重感染,而且在一些特殊情况下也可能与多种寄生虫发生多重感染.在亚洲和东非部分国家开展的流行病学研究显示,结核病患者中约有2.6％～77％感染了不同的寄生虫,呈现出虫种和地区的差异.多项研究表明,与被单一病原体感染相比,结核菌和寄生虫的双重感染能够降低宿主机体免疫机能,使结核病患者的临床症状加重、病程延长、治疗预后差.某些寄生虫病,尤其是肺部寄生虫病,与结核病具有相似的临床表现及肺部影像学特征,易被误诊为结核病,从而导致治疗延误.
Although tuberculosis （TB） and parasitic diseases are two independent major health problems world- wide, their relationship should not be neglected because co-infection of Mycobacterium tuberculosis （MTB） and parasites and misdiagnosis of TB and parasitic diseases were reported in many areas. In addition to the co-infection of MTB and sin- gle parasite, MTB and multiple parasites can also coexist in humans under some special conditions. About 2. 6%-77% of TB cases were infected with different parasites in some countries of Asia and East Africa, which suggests significant differ- ence of species and region about co-infection. Compared with single pathogen, co-infection may significantly inhibit the host＇ s immune system, increase antibacterial therapy intolerance and be detrimental to the prognosis of the disease. Some parasitic diseases, especially pulmonary parasitoses, have clinical manifestations and imaging characteristics in lung, simi- lar to TB, which easily leads to being misdiagnosed as TB and delay in the treatment.
出处
《中华疾病控制杂志》
CAS
北大核心
2014年第1期63-67,共5页
Chinese Journal of Disease Control & Prevention
基金
科技部重大专项(2012ZX10004-220)
关键词
结核
寄生虫病
误诊
Tuberculosis
Parasitic diseases
Misdiagnosis
