重和林M30联合盐酸二甲双胍缓释胶囊治疗2型糖尿病疗效分析被引量：5

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摘要目的分析精蛋白重组人胰岛素注射液(预混30/70,重和林M30)联合盐酸二甲双胍缓释胶囊治疗2型糖尿病的临床效果。方法 40例2型糖尿病患者给予重和林M30联合盐酸二甲双胍缓释胶囊治疗。比较治疗前后的空腹血糖(FBG)、餐后2h血糖(2hPBG)、糖化血红蛋白水平(HbA1c)及不良反应发生情况。结果治疗后FBG、2hPBG、HbA1c均低于治疗前,差异有统计学意义(P<0.05)。治疗前后BMI差异无统计学意义(P>0.05)。治疗过程中出现轻度低血糖反应1例。结论重和林M30联合盐酸二甲双胍缓释胶囊治疗2型糖尿病安全性高,患者耐受性及依从性良好,值得临床推广应用。

作者胡文标周燕苏虹苏迈

机构地区南宁市红十字会医院内科一病区

出处《临床合理用药杂志》 2014年第4期40-40,共1页 Chinese Journal of Clinical Rational Drug Use

关键词糖尿病 2型重和林M30 二甲双胍

分类号 R587.1 [医药卫生—内分泌]

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1中国2型糖尿病防治指南（2010年版）[J].中国实用乡村医生杂志,2012,19(4):1-15. 被引量：329
2陆在英,钟南山.内科学[M].7版.北京:人民卫生出版社,2008:256-260.
3谢爱侠,纪立农.胰岛素治疗在2型糖尿病早期的应用[J].上海医药,2006,27(5):209-211. 被引量：13

二级参考文献16

1UK Prospective Diabetes Study (UKPDS) Groups.Inensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)[J].Lancet,1998,352(9131):837.
2Ohkubo Y,Kishikawa H,Araki L,et al.Intensive issulin therapy prevents the progression of diabetic microvascular complications in Japanese with non-insulin-dependent diabetes mellitus:a randomized prospective 6-yesr study[J].Diabetes Res Clin Pract 1995,28(2):103.
3Turner RC,Millns H,Neil HAW,et al.Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus:United Kingdom Prospective Diabetes Study (UPKDS:23)[J].BMJ 1998,316(7134):823.
4Usitupa MI,Niskanen LK,Siitonen O,et al.Ten-year cardiovascular mortality in relation to risk factors and abnormalityes in lipoprotein composition in type 2 (non-insulin-dependent) diabetic and non-diabetic subjects[J].Diabetologia,1993,36(11):1175.
5Rohlfing CL,Wiedmeyer,Little RR,et al.Defining the relationship between plasma glucose and HbA1c:ananlysis of glucose profiles and HbA1c in the Diabetes Control and Complications Trial[J].Diabetes Care,2002,25(2):275.
6Wright A,Burden ACF,Paisey RB,et al.Sulfonylurea inadequacy:efficacy of addition of insulin over 6 years in patients with type 2 diabetes in the UK.Prospective Diabetes Study(UKPDS57)[J].Diabetes Care,2002,25(2):330.
7Turner RC,Cull CA,Frighi V,Holman RR.Glycemic control with diet,sulphonylurea,metformin,or insulin in patients with type 2 diabetes mellitus:progressive requirement for multiple therapies (UKPDS 49)[J].JAMA,1999,281(21):2005.
8United Kingdom Prospective Diabetes Study Group.United Kingdom Prospective Diabetes Study (UKPDS013:relative efficacy randomly allocated diet,sulphonylurea,insulin,or metformin in patients with nemly diagnosed non-insulin dependent diabetes followed for three years)[J].BMJ,1995,310(6972):83.
9United Kingdom Prospective Diabetes Study Group.U.K.Prospective diabetes study 16.Overiew of 6 years' therapy of type Ⅱdiabetes:A progressive disease Diabetes[J].Diabetes,1995,44(11):1249.
10Stratton IM,Adler AI,Neil HA,et al.Association of glycaemia with macrovascular and microvascular coplication of type 2 diabetes(UKPDS 35):Lprospective observational study[J].BMJ,2000,321(7258):405.