摘要
传统汤剂(TD)是中医治病的重要武器,而其制备不便等弊端严重制约其应用。中药配方颗粒(DGCM)改进了其诸多弊端,但长期未能有效推广,根本原因之一是DGCM汤剂(DGD)与TD的差异规律等基础研究薄弱。应根据中医药理论,化繁为简,以相须药对研究为切入点,通过获取LC-MS指纹图谱、血清指纹图谱、药效学等多层次指标信息,基于多种数据处理方法,进行多层次结合、横纵向结合、主客观结合(权重)、图形化与抽象化结合的定性定量对比,从而综合判别其是否可等效替代,并提出不等效时的处理方法。在此基础上全面总结DGD和TD的共性差异规律,凝练其初步的药性特点,为汤剂改革及DGCM的科学合理应用奠定基础。
The traditional decoction （TD） is an important weapon of the Chinese medicine treatment, and its many shortcomings such as preparation inconvenience seriously restrict its application. Dispensing Granule of Chinese Medicine （DGCM） considerably improved its most shortcomings, but for a long time it has not been effectively and widely popularized, one of the fundamental reason is that the foun- dational research on the differences between DGCM decoction （DGD） and TD is not enough. The new ideas of the reform of TD and the research of DGCM, which should accord to Chinese medicine theory, making things simple and research on mutual promotion of couplet medicines as the breakthrough point, by obtaining the multi-index information of LC-MS fingerprints, serum fingerprint and pharmacody- namics, and base on a variety of data processing methods to carry out the qualitative and quantitative comparison of combination of multi-level, combination of horizontal and vertical integration, combination of subjective and objective （weight）, combination of graph- ical and abstract combination,thus to judge whether it can be equivalent alternative comprehensively, raising approach when they are non-equivalent. On this basis, sum up differentia regularity between DGD and TD, and condense initial potency characteristics,which lay the foundation for the decoction reform and scientific and rational application of DGCM.
出处
《中医学报》
CAS
2014年第2期239-241,共3页
Acta Chinese Medicine
基金
国家自然科学基金青年基金项目(编号:81001646)
关键词
中药配方颗粒
中药汤剂改革
药对
单味药
“相须”
dispensing granule of Chinese medicine
reform of traditional Chinese medicine decoction
couplet medicines
single drug
mutual promotion
