摘要
铁过载是指体内铁负荷过量,可伴或不伴器官功能障碍。在继发性铁过载疾病中,除外输血,一组表现为无效造血的贫血性疾病,即使无输血依赖,也可发生铁过载。目前发现铁调素等分子在铁过载的发生中发挥重要作用。本文参考目前国内外最新研究,主要阐述无效造血导致铁过载的机制及最新进展。
Iron overload refers to a condition resulting in increased body iron stores,with or without organ dysfunc-tion. Among the secondary iron overload syndromes,besides blood transfusion dependency,a group of anemias that arise from ineffective erythropoiesis may manifest a feature of iron overload. A group of candidate molecules such as hepcidin are identified to serve as vital＂singles＂in the process. With the up-to-date research achievements of this field,this review mainly states the mechanism and the latest development that how ineffective erythropoiesis cause tissue iron overload.
出处
《基础医学与临床》
CSCD
北大核心
2014年第1期121-124,共4页
Basic and Clinical Medicine
基金
国家自然科学基金(8107040)
卫生公益性行业科研专项经费(201202017)
关键词
无效造血
铁过载
铁调素
ineffective erythropoiesis
iron overload
hepcidin
