摘要
胃癌是我国最常见的恶性肿瘤之一,其死亡率占我国恶性肿瘤死亡率之首。胃癌的病因复杂,虽经数十年的研究,至今仍无明确定论。目前普遍认为其发生是遗传和环境因素共同作用的结果。随着对表观遗传学认识的深入,遗传因子在疾病中的作用被不断发现,对疾病的诊断、治疗和预防起到了一定的作用。本文结合Caveolae蛋白的研究现状综述其与胃癌发生发展的表观遗传学关系,希望对胃癌发病机制的研究提供新的思路。
Gastric Carcinoma（GC） is one of the most common malignant tumors, and it is the leading cause of cancer deaths. The causes of GC are complicated. Although decades of researches on the causes of gastric carcinoma have been done,the definite etiology and pathogenesis are not clear yet. Many studies have suggested that environmental and genetic factors may play important roles. As sci- entists learn more about epigenetics,the role of genes in diseases are constantly being discovered that contributes to the diagnosis, treat-ment and prevention of diseases. This review summarized the role of Caveolae protein in the genesis and development of gastric carcino-ma, looking forward to providing new insights into the causes of gastric carcinoma.
出处
《川北医学院学报》
CAS
2013年第6期596-599,共4页
Journal of North Sichuan Medical College
基金
包头市科技计划项目(2011S2012-01-12)
