摘要
目的探讨结直肠颗粒细胞瘤(granular cell tumor,GCT)的临床病理特征、诊断及鉴别诊断、治疗和预后。方法对7例结直肠颗粒细胞瘤的临床病理和免疫组织化学特点进行分析比较,并结合相关文献复习。结果 7例结直肠GCT组织学形态相似,瘤细胞呈巢状或者片状排列,瘤细胞体积比较大,形态较单一,圆形或多边形,胞质较丰富,呈嗜酸性颗粒状。免疫组化结果显示,瘤细胞S-100、CD68、vimentin及NSE均阳性,而CD117、Dog-1、CD34、SMA、CgA、EMA及CK均阴性。结论发生于结直肠的GCT非常罕见,由于其缺乏特征性的临床表现及内镜特征而极易被误诊为胃肠道间质瘤或者平滑肌瘤,但依靠特征性的组织形态学并结合免疫组织化学有助于其诊断及鉴别诊断。
Objective To discuss the clinicopathological features, diagnosis and differential diagnosis, treatment and prognosis of colorectal granular cell tumor（GCT）. Methods The clinicopathological and immunohistochemistry expression were retrospectively ana- lyzed in seven cases of GCT with the review of the literatures. Results Microscopically,the tumor cells of colorectal GCT were arranged in sheets or nests. The tumor cells were big in size and uniform in shape （round or polygonal） and full of abundant eosinophilic cytoplasm. Immunohistochemically, the tumor cells were positive for S - 100, CD68, vimentin and NSE, while CD117, Dog - 1, CD34, SMA, CgA, EMA and CK were negative. Conclusion GCT is rare in colorectal sites. It may be misdiagnosed as gastrointestinal stromal tumor or leio- myoma due to the lack of characteristic clinical manifestations and endoscopic characteristics. Diagnosis and differential diagnosis should be made in combination with immunohistochemical staining and histologic examination.
出处
《医学研究杂志》
2014年第1期64-66,共3页
Journal of Medical Research
基金
浙江省医学扶植重点建设学科计划(GJSX-010-004)
关键词
结肠
直肠
颗粒细胞瘤
Colon
Rectum
Granular cell tumor
