摘要
通过查阅近十年来关于枳实/枳壳的文献记载,将枳实、枳壳的抗抑郁作用总结为4个方面,分别是提高海马糖皮质激素受体(glucocorticoid receptor,GR)mRNA表达、抑制下丘脑—垂体—肾上腺皮质轴亢进;提高海马及皮质脑源性神经营养因子(brain-derived newrotrophic factor,BDNF)mRNA表达;参与提高神经递质类表达和释放,如5-羟色胺、去甲肾上腺素(norepinephrine,NE)、多巴胺(dopamine,DA)的释放;调节胃肠激素、增加胃肠动力,能显著增加胃泌素(gastrin,GAS)、胃动素(motilin,MTL),增加胃排空率和肠推动力;但作用机制尚不明确,仍需进一步验证。
Through cosuhing the literatures about Aurantii Fructus Immaturus/Aurantii Fructus in the recent ten years, four main ways of antidepressant effects were came up ： promoting the expression of hippocampal glucocorticoid receptors mRNA to inhibit the hyperfunction about HPA axis; booting the pro duction of hippocampal brain-derived neurotrophic factor mRNA; participating in improving the expression of neurotransmitters, like 5-HT, NE, DA ; regulating the gastrointestinal hormones, for example increasing the level of GAS/MTL to improve gastric emptying rate, to enhance its function. However, these four as pects still needs further experimental research to examine its reliability and validity.
出处
《环球中医药》
CAS
2014年第1期77-80,共4页
Global Traditional Chinese Medicine
基金
国家自然科学基金项目(81072801)
北京市中医管理局项目(JJ2011-84)
关键词
枳实
枳壳
抗抑郁作用
下丘脑一垂体一肾上腺皮质轴
脑源性神经营养
因子
神经递质
Aurantii Fructus Immaturus
Aurantii Fructus
Antidepressant effect
Hypo-thalumic-pituitary-adrenal axis
Brain-derived newrotrophic factor
Eurotransmitter
