摘要
目的评价声触诊组织定量(virtual touch tissue quantification,VTQ)技术在IgA肾病(IgA nephropathy,IgAN)的应用价值。方法选择2012年1月1日至4月30日北京协和医院经肾活检证实的28例IgAN患者,对所有患者左肾进行常规超声(肾脏长径、皮质厚度、叶间动脉阻力指数)及VTQ超声[剪切波速度(shear wave velocity,SWV)]检查。分析常规超声与VTQ指标间,以及各超声指标与患者临床/病理指标-慢性肾脏病(chronic kidney disease,CKD)分期、Lee分级、肾小球硬化指数(glomerular sclerosis index,GSI)、肾小管萎缩(tubular atrophy,TA)以及肾间质纤维化(interstitial fibrosis,IF)的相关性。结果 IgAN患者肾脏常规超声指标与其VTQ结果、临床/病理指标无显著相关性(P>0.05);VTQ测定的SWV与CKD分期(r=-0.382,P=0.045)、Lee分级(r=-0.407,P=0.031)及IF(r=-0.397,P=0.036)呈负相关,与GSI和TA无显著相关性(P>0.05)。结论通过VTQ技术测定的肾皮质SWV与多项临床/病理指标存在相关性,这一新型超声弹性成像技术的临床意义值得进一步研究。
Objective To evaluate the application of virtual touch tissue quantification （VTQ） technique in immunoglobulin A nephropathy （IgAN）. Methods A total of 28 patients were included in present study who underwent kidney biopsy in Peking Union Medical College Hospital from January 1,2012 to April 30, 2012. On sonography, conventional [ length （L）, thickness （W）, resistive index （RI） ], and VTQ （shear wave velocity, SWV） parameters of left kidney were measured. Then using Spealnnan correlation analysis, the correlations be- tween SWV and clinicopathologic parameters [ chronic kidney disease （CKD） stage, Lee grade, glomerular scle- rosis index （GSI）, tubular atrophy （TA）, interstitial fibrosis （IF）] and the association of SWV and conven- tional ultrasound measurements were evaluated. Results No significant correlation was found between conven- tional ultrasound measurements and SWV, as well as clinicopathologic parameters （ all P 〉 0.05 ）. However, Spearman analysis indicated that SWV showed significant correlations with CKD stage （ r = - 0. 382, P = 0.045）, Lee grade （r= -0.407, P=0.031）, and IF （r= -0.397, P=0.036）. Conclusions Asanovel sono-elastography technique, VTQ correlates with multiple clinicopathologic parameters by measuring renal corti- cal stiffness. Therefore it is of great value in clinical application and warrants further investigation.
出处
《协和医学杂志》
2014年第1期50-53,共4页
Medical Journal of Peking Union Medical College Hospital
关键词
声触诊组织定量技术
IGA肾病
弹性成像
病理
virtual touch tis,sue quantification
immunoglobulin A nephropathy
elastography
pathology
