摘要
目的探讨药品不良反应的食物因素。方法收集国内外与食物有关的药品不良反应文献报道,分析其发生机制。结果食物可影响药物的理化性质及药动学特性,可协同或拮抗药物的药效和毒性。食物对药物的影响可能与食物中某种或多种营养成分有关。结论应加强药品不良反应中食物因素的研究,注意分析总结食物对药物疗效及安全性的影响,为临床安全用药提供数据支持。
Objective To explore the diet factor of adverse drug reactions. Methods The domestic and foreign diet-related adverse drug reactions reported in the literature were collected, and the mechanism was analyzed. Results Diet can affect drug physicochemical properties and pharmacokinetic properties. The synergistic or antagonistic interactions between diet and drug may affect the efficacy and toxicity of drugs. The diet-related adverse drug reactions may be associated with certain nutrient or multiple nutrients in the diet. Conclusion In order to provide data to support the clinical safety of medication, the research of diet factor of adverse drug reactions should be strengthened, and the impact of diet on drug efficacy and safety should be analyzed and summarized.
出处
《中国药物警戒》
2014年第1期35-38,共4页
Chinese Journal of Pharmacovigilance
