摘要
目的 :探讨缺血预处理对脑缺血再灌注损伤两相保护作用的特点。方法 :低压低灌下阻断双侧颈总动脉诱导脑缺血。脑预缺血 3分钟、灌注 30分钟 (快速相 )或 3天 (延迟相后 ) ,再缺血 10分钟 ,灌注 3天或 7天后测海马CA1区神经元密度。结果 :与缺血 10分钟组相比 ,快速相或延迟相组再缺血后第 3天神经元密度明显增高 (P<0 0 5 ) ;与延迟相组相比 ,快速相组再缺血后第 7天神经元密度明显减少 (P <0 0 5 )。结论 :预缺血对脑缺血再灌注损伤的保护作用有快速和延迟两个时相 。
Objective: To evaluate the characteristics of two phase protective effects of ischemic preconditioning (IPC) on the cerebral ischemia reperfusion injury. Methods: Cerebral ischemia was produced by occlusion of both carotid arteries in combination with systemic hypotension. The preconditioning ischemic insult lasted 3 minutes and recovered reperfusion of 30 minutes (rapid phase) or 3days (delayed phase), and the test ischemia lasted 10 minutes. Neuronal density was measured in CA1 region of hippocampus on the third or seventh day of reperfusion after the test ischemia. Results: The neuronal density on the third day after test ischemia in the group of rapid or delayed phase was significantly higher than that in 10 minutes ischemic group(P<0.05). As compared with those in the group of delayed phase, the neuronal density on the seventh day after test ischemia in the group of rapid phase was decreased markedly (P<0.05). Conclusions: There are two phases in protective effects of IPC on the cerebral ischemia reperfusion injury, but IPC's delayed phase can provide better cerebral protection than its rapid phase.
出处
《泸州医学院学报》
2000年第6期453-455,共3页
Journal of Luzhou Medical College
基金
云南省应用基础研究基金资助项目
