摘要
目的探讨大蒜素对幽门螺杆菌(HP)阴性慢性萎缩性胃炎的治疗作用。方法采用前瞻性、自身对照方法,选择2010年1月至2012年6月于本院经胃镜加病理确诊的慢性萎缩性胃炎并HP阴性患者,共69例,所有患者常规服用大蒜素24周。对治疗前、治疗12、24周分别进行临床症状评分,治疗前、治疗24周分别行胃镜检查并取标本行组织病理检查,比较治疗前后的变化。结果治疗12、24周患者较治疗前临床症状评分下降,差异均具有统计学意义(P均<0.05);治疗24周后较治疗前内镜下表现、组织病理评分均有明显改善,差异具有统计学意义(P均<0.05)。结论大蒜素可显著改善HP阴性慢性萎缩性胃炎患者的临床症状、内镜下表现及组织病理情况,值得临床进一步研究。
Objective To explore the therapeutic effects of the allicin on patients with chronic atrophic gastritis （CAG） of Helicobacter pylori （HP） negative. Methods By prospective, self-control study, total of 69 patients with HP negative CAG diagnosed by the gastroscopy and pathological examination were investigated in Qingdao Municipal Hospital during January 2010 to June 2012, and all the patients took allicin for 24 weeks. The clinical symptoms before treatment and 12, 24 weeks after therapy were evaluated, and findings of gastroscopy and histology of gastric mucosa were recorded and compared before and after the treatment. Results Clinical symptom scores decreased after 12 and 24 weeks of treatment than before, with significant difference （P 〈 0.05）. The endoscopic performance, the pathology score were all improved before and after therapy, with significant difference （P 〈 0.05）. Conclusions Allicin could significantly improve the clinical symptoms, endoscopic performance and pathological situation of CAG patients with HP negative, worthy of further clinical research.
出处
《中华实验和临床感染病杂志（电子版）》
CAS
2013年第6期67-70,共4页
Chinese Journal of Experimental and Clinical Infectious Diseases(Electronic Edition)
基金
2011年青岛市科技计划基础研究项目[No.12-1-4-16-(4)-jch]
关键词
大蒜素
慢性萎缩性胃炎
疗效
Allicin
Atrophic gastritis,chronic
Curative effect
