摘要
目的探讨细胞间黏附分子(ICAM-1)、P-选择素(P-selectin)、D二聚体(D-dimer)在子痫前期发生发展中的作用。方法随机选取子痫前期患者39例为研究组,37例正常妊娠孕妇为对照组,采用免疫组织化学技术检测两组胎盘组织中ICAM-1、P-selectin的表达情况;采用酶联免疫吸附法(ELISA)检测两组血浆ICAM-1、P-selectin和D-dimer的表达水平。结果子痫前期组胎盘ICAM-1、P-selectin的表达明显高于对照组(P<0.05);两组血浆均有ICAM-1、P-selectin和D-dimer的表达,子痫前期组的血浆ICAM-1、P-selectin和D-dimer表达明显高于对照组(P<0.05)。结论子痫前期患者ICAM-1、P-selectin和D-dimer表达升高可能与子痫前期的发生发展有关,监测这些指标对病情判断及指导治疗具有重要意义。
Objective ： To investigate the role of ICAM - 1, P - selectin and D - dimer in the development of preeclampsia. Meth- ods： ICAM - 1 and P - selectin were detected by immunohistochemistry in placental tissue and ELISA method was used to detect the expression of ICAM - 1, P - selectin and D - dimer in maternal plasma from 76 cases of patients （39 cases of preeclampsia, 37 normal pregnant women）. Results ： There were significant differences on the expression of ICAM - 1 and P - selectin in placenta （ P 〈 0. 05 ）. All groups showed ICAM - 1, P - selectin and D - dimer positive expression in maternal plasm. ICAM - 1, P - selectin and D - dimer expression were also significantly different between the two groups in the maternal plasm （ P 〈 0. 05）. Conclusions. The high levels of ICAM - 1, P - selectin and D - dimer in preeclampsia may be associated with the occurrence and development of preeclampsia, it is important to monitor the changes for the judgment of the disease and treatment.
出处
《中国优生与遗传杂志》
2014年第2期59-61,共3页
Chinese Journal of Birth Health & Heredity
