摘要
目的 研究缺碘与高碘对大鼠甲状腺抗氧化能力的影响 ,探讨自由基对甲状腺的损伤作用。方法 将 Wistar大鼠随机分为 3组 :适碘组 (NI)、高碘组 (HI)、低碘组 (L I) ,观察喂养 12周、2 4周大鼠甲状腺及全身抗氧化能力的改变。结果 低碘组大鼠血清超氧化物歧化酶 (SOD)、谷胱甘肽过氧化物酶 (GSH- Px)与同期适碘对照组比较无明显变化 ,丙二醛 (MDA)在实验的第 2 4周显著升高 ;甲状腺组织匀浆 SOD、GSH - Px和 MDA在 12周和 2 4周均明显升高 ;甲状腺生物膜 SOD和 MDA在 12周和 2 4周均明显高于同期适碘对照组。高碘组血清、组织匀浆及甲状腺生物膜 SOD、GSH- Px和 MDA在实验过程中均无明显改变。结论 碘缺乏可导致 Wistar大鼠甲状腺组织过氧化损伤 ;而碘过多在本实验期间未表现出对甲状腺的明显损伤作用。
Objective The experiment was designed to study the effect of iodine deficiency and iodine excess on antioxidative ability of rats thyroid and the action of free radical in thyroid peroxidition damage.Methods The rats were divided into three groups randomly,normal iodine group(NI),low iodine group (LI) and high iodine group (HI).Biochemical method was used to determine the activity of SOD,GSH Px and MDA level not only in thyroid tissue homogenization,thyroid biomembrane but also in serum at 12 and 24 weeks.Results In low iodine group the activity of SOD,GSH Px and MDA levels were higher than those of NI group in thyroid tissue homogenization,thyroid biomembrane and serum during experiment.In HI group the activity of SOD,GSH Px and MDA levels in tissue homogenzation,thyroid biomembrane and serum were no difference compared with the NI group.Conclusions [WT5”,6BZ]Iodine deficiency may change the activity of antioxidation and caused the damage of thyroid by free radical,while iodine excess had not shown marked effects on the capacity of antioxidation of thyroid.
出处
《中国地方病学杂志》
CAS
CSCD
北大核心
2001年第1期11-13,共3页
Chinese Jouranl of Endemiology
基金
国家自然科学基金资助项目!( 3 9870 682 )
