摘要
目的 调查学龄期肥胖儿童甲状腺机能及性腺发育状况。方法 测定了 6 0例 9～ 12岁肥胖儿童血清甲状腺激素和性激素水平 ,观察了性征发育状况。结果 肥胖儿童的身高与对照组相似 ,而体重及体重指数显著高于对照组。肥胖儿童的血清游离三碘甲状腺原氨酸 (FT3)显著高于对照组 ;肥胖儿童组的尿碘中位数为 180μg/ L,明显低于正常体重儿童组。女性肥胖儿童的血清卵泡刺激素 (FSH)水平显著低于对照组 ,而雌二醇 (E2 )水平明显高于对照组 ;男性肥胖儿童的性激素水平与对照组间差异无显著意义 ;肥胖儿童的性征发育早于对照组。结论 学龄期儿童肥胖症对甲状腺功能有所影响 ,并致性腺发育期提前。
Objective The aim of our study was to investigate the thyroid and gonadal functions in obese children aged 9~12 years old.Methods Serum thyroid and six steroid hormones were measured in both obese children and their control.Results Obese children were found to have significantly higher body weight index (BMI) than that in control.It turned out that free 3,5,3'-thiiodothyronine(FT 3) in obese children were significantly increased (6.0±1.3 vs 3.5±0.6).The result of urinary iodine measurement in obese children showed that the median urinary iodine excretion level was lower than that in control (180 μg/L vs 269 μg/L).Serum FSH level was significantly lower and E 2 level was significantly higher in obese girls than those in control(3.3±0.8 vs 4.8 ±2.2 ng/L,P<0.05 of FSH,90±35 vs 23±6 ng/L,P<0.01for E 2).Gonadal development and maturity took place earlier in the obese children than in control.Conclusions These results suggested that,obesity may interfere in thyroid metablism function;obesity may be responsible for the earlier gonadal development and maturity.
出处
《中国地方病学杂志》
CAS
CSCD
北大核心
2001年第1期41-42,共2页
Chinese Jouranl of Endemiology
基金
卫生部全国地方病防治办公室资助项目!( 1996)
