摘要
目的调查江苏常熟地区女性人乳头瘤病毒(HPV)感染及其亚型的分布情况。方法应用DNA导流杂交技术对1 602例妇科门诊患者进行HPV基因分型检测。结果 1 602例患者中阳性患者为719例,感染率为44.9%,共检出20种HPV型别,其中单一感染者498例,占阳性人数的69.3%,二型感染者162例,占阳性人数的22.5%,三型或三型以上者59例,占阳性人数的8.2%,阳性患者中高危型的依次以16,52,68,31,33为主,低危型以11、6为主。结论常熟地区妇女感染HPV率较高,以单一感染为主,主要为16型,其次为52,68,31,33型。作为宫颈癌筛查的有效手段,一次PCR检测多种HPV亚型的分子杂交技术有利于对HPV亚型多重感染的诊断和宫颈癌的防治有重要意义。
Objective To investigate the distribution of HPV and its subtypes in Changshu,Jiangsu province. Methods DNA diversion hybridization was employed to analyze HPV gene types of 1602 outpatients. Results 719 patients were positive. The infection rate was 44.9%. 20 types of HPV were identified, of which infection with single type was 498 （69.3%） , infection with 2 types was 162 （22.5 % ） ,infection with 3 or more than 3 was 59 （8.2%）. Patients with high risk type in positive group were mainly 16,52,68,31,33 types,low risk type were mainly 11 and 6 type. Conclusions HPV infection rate in women of Changshu district was high and mairdy with single type infection. Most of them were infected with 16 type, followed by the type of 52,68,31,33. As an effective screening method for eetwieal carcinoma,DNA diversion hybridization was of great importance for HPV mtdti-type infection and prevention of cervical carcinoma.
出处
《安徽医药》
CAS
2014年第1期81-83,共3页
Anhui Medical and Pharmaceutical Journal
