摘要
目的统计该院2009年1月—2012年6月的药品不良反应(adverse drug reaction,ADR)病例,总结其特点及规律,为临床合理、安全用药提供预警信息。方法回顾性分析该院近三年半以来的596例药物不良反应患者的基本情况、给药途径、药品种类、临床表现及其转归情况,并采用统计学方法总结分析药物不良反应发生的规律及原因。结果本组596例患者中大于60岁的患者约占16.8%,给药途径中由静脉给药引发的ADR最为常见(74.2%),引发药物不良反应的药品中由抗菌药物引发的药物不良反应病例最多(47.5%),药物不良反应的靶器官统计结果提示皮肤及其附件为最常见的受累器官(37.9%)。结论临床上应该进一步加强ADR的监测和报告工作,需进一步规范抗菌药物的使用,为提高临床用药水平提供指导。
Objective To analyze 596 ADR （adverse drug reaetion,ADR） cases in a hospital from January 2009 to June 2012,to summarize the characteristics and disciplinarian of ADR,in order to provide rational and sate medication for clinical treatment. Methods A retrospective analysis was made of 596 ADR cases of our hospital in the past three and half years. We analyzed the basic situation of route of administration ,types of drugs, clinical manifestations and outcome of the situation. Statistical methods were used to analyze the regularity and the cause of ADR. Results Of 596 ADR eases,patients older than 60 years accounted for approximately 16.8% ,which was slightly higher than other groups. The intravenous route of administration caused most conamon ADR （74.2%） ;the antibiotics caused larghest number of adverse drug reactions（47.5% ） ,Target organ statistical results of adverse drug reactions suggested that skin and its appendages were the most conamon organ involvement （37.9%）. Conclusions it＇ s important to further strengthen monitoring and reporting of ADR in clinical task. We need to regulate the use of antibiotics. Clinical pharmacists play a major role in ADR monitoring,which can improve rational use of drugs in the clinical practice.
出处
《安徽医药》
CAS
2014年第1期199-201,共3页
Anhui Medical and Pharmaceutical Journal
关键词
药品不良反应
监测
合理用药
adverse drug reactions
monitoring
rational use of drugs
