摘要
[目的]探讨HIF-1α、VEGF和pVHL在肾透明细胞癌(clear cell renal cell carcinoma,CCRCC)中的表达水平及与临床病理特征的关系。[方法]采用免疫组化法检测55例CCRCC中HIF-1α、VEGF和pVHL 3种蛋白的表达,并对其与临床分期、病理分级、淋巴结转移及预后关系作相关性分析。[结果]52例获得随访,5年内共有12例死亡。HIF-1α和VEGF在55例CCRCC中阳性表达率分别为58.2%,100.0%,pT3/pT4期组强表达率(72.7%、54.5%)显著高于pT1/pT2期组(29.5%、20.5%)(P<0.05);高级别组(75.0%、41.7%)显著高于低级别组(27.9%、23.3%)(P<0.05);两者高表达与淋巴结转移及中位生存时间密切相关(P<0.05),且两者表达存在正相关关系(r=0.37,P<0.05)。pVHL阳性表达率为52.7%(29/55),与病理分级、临床分期、淋巴结转移及HIF-1α均无明显相关性(P>0.05)。[结论]HIF-1α和VEGF在肾透明细胞癌中的表达可作为预测患者预后的指标,共同强表达预示生存时间短,对临床早期干预治疗具有重要的指导意义。
[Purpose] To investigate expressions of HIF-lα,VEGF and pVHLin clear cell renal carcinoma （CCRCC） and their clinical significance. [Methods] The protein expressions of HIF- lα,VEGF and pVHL in CCRCC were evaluated immunohistochemically and the correlation a- mong their expressions ,clinical stage ,pathological grade ,lymph node metastasis and prognosis was analyzed. [ Results ] Fifty-two cases were followed up, and 12 cases died in 5 years. The ex- pressions of HIF-lα and VEGF in 55 patients with CCRCC were 58.2% and 100.0% respec- tively,and their expressions in stage pT3/pT4 group （72.7% and 54.5%） were significantly higher than those in stage pTt/pT2 group （29.5% and 20.5%）（P〈O.O5）;and their expressions in high grade patients （75.0% and 41.7%） were higher than those in low grade patients （27.9% and 23.3%） （P 〈0.05）.High expressions of HIF-lα and VEGF significantly correlated with lymph node metastasis and median survival （P〈O.O5）,and a positive correlation between HIF-Iα and VEGF was found （r=0.37, P〈O.05）. Positive expression of pVHL was 52.7% （29/55） in CCRCC patients,which had no correlation with pathological grade,or clinical staging,or lymph node metastasis, or HIF- 1α（P〉0.05）. [ Conclusion ] HIF- 1 α and VEGF expression might be biomarker for assessment of CCRCC prognosis. Their strong coexpression in CCRCC predicts short sur- vival,which plays an important significance for early intervention treatment of CCRCC.
出处
《肿瘤学杂志》
CAS
2014年第1期59-63,共5页
Journal of Chinese Oncology
基金
温州市鹿城区科技计划项目(S090201)
