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2',3'-O-异丙叉五碳环腺苷的全合成

Total Synthesis of 2',3'-O-isopropylidenearisteromycin
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摘要 以甲基-α-D-吡喃甘露糖苷为原料,经碘代、还原、Wittig缩合、复分解关环、氧化、Michael加成、Mitsunobu反应、氧化及氨解等9步反应合成了一个五碳环腺苷类化合物重要中间体——2',3'-O-异丙叉五碳环腺苷,总产率20%,其结构经1H NMR,13C NMR确证。 An important intermediate of carbocyclic adenosine analogue,2＇,3＇-O-isopropylidenearisteromycin,with the total yield of 20% was synthesized by a nine-step reaction using methyl-α-D-mannopyranoside as the starting material. The structure was confirmed by1H NMR and13C NMR.
作者 许芝祥 尹伟 陈晶磊 乔春华
机构地区 苏州大学药学院
出处 《合成化学》 CAS CSCD 北大核心 2014年第1期68-71,共4页 Chinese Journal of Synthetic Chemistry
基金 国家自然科学基金资助项目(81072514) 国家自然青年科学基金资助项目(21002067)
关键词 甲基-α-D-吡喃甘露糖苷 碳环腺苷 全合成 methyl-α-D-mannopyranoside carbocyclic adenosines total synthesis
分类号 O629.11 [理学—有机化学]
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参考文献10

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共引文献6

合成化学
2014年 第1期

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