摘要
目的比较婴幼儿呼吸道合胞病毒(RSV)和人鼻病毒(HRV)急性下呼吸道感染的临床特征,探讨婴幼儿期RSV急性下呼吸道感染患儿后期哮喘和反复喘息的发生与HRV感染患儿是否存在差异。方法采用RT-PCR或PCR方法检测住院患儿咽拭子或鼻咽吸取物中常见的呼吸道感染病毒,选取单一RSV和HRV感染病例,回顾性比较两组患者的临床特征并进行随访。结果 RSV感染组纳入病例80例,HRV感染组纳入32例。两组患儿的临床特征相似,但RSV感染组患儿年龄偏小(P=0.004),有喘息表现者明显多于HRV感染组(P=0.000)。在与哮喘和反复喘息发生的关系上,两组间的差异无统计学意义(P值均为1.000)。结论婴幼儿RSV和HRV急性下呼吸道感染的临床特征相似,但在平均年龄、临床喘息的发生率等方面存在统计学差异。未发现婴幼儿期RSV感染患儿后期哮喘和反复喘息的发生与HRV感染患儿间存在差异。
Objective To compare the clinical features of acute lower respiratory tract infection （ALRTI） with single RSV and HRV infection in infant, and to explore the differences of relationship between asthma and recurrent wheezing and the RSV or HRV infection.Methods Hospitalized patients with ALRTI from March 2007 to May 2010 were involved in this study. RT-PCR or PCR methods were applied to detect common respiratory tract viruses including respiratory syncytial virus （RSV）, human rhinovirus （HRV）, influenza virus （IFV）, parainfluenza virus （PIV） type 1-4, adenovirus （ADV）, enterovirus （EV）, human coronavirus （HCOV）, human meta pneumonia virus （HMPV） and human bocavirus （HBOV）. Clinical feature of patients with single RSV and HRV infection were compared. Follow-up was carried out to investigate the incidence of recurrent wheezing or asthma after RSV and HRV infection. Results Eighty patients with single RSV infection and 32 patients with single HRV infection were enrolled into this study. All the patients with a normal white blood cell and C reactive protein. The mean age was （4.7±5.0） months in patients with RSV infection, and （9.8±8.8） months in patients with HRV infecton. A significant difference of the mean age between RSV group and HRV group （P=0.004） was found. The clinical features of ALRTI with RSV infection were similar with that of ALRTI with HRV infection in infant. However, the incidence of wheezing was lower in HRV infection patients （P=0.000）. According to the follow-up study, no significant differences in the incidence of recurrent wheezing and asthma between the two group patients were found （P=1.000）.ConclusionsThe clinical features of ALRTI with RSV infection are similar with HRV infection in infant, except in mean age, incidence of wheezing. There are no significant differences in the incidence of recurrent wheezing and asthma between the two group patients.
出处
《中华临床医师杂志（电子版）》
CAS
2013年第21期20-22,共3页
Chinese Journal of Clinicians(Electronic Edition)
基金
"十二.五"卫生部科技重大专项课题(2012ZX10004206-004)
国家科技支撑计划课题(2012BAI03B02)
