摘要
目的分析脑外伤合并骨折患者血清胰岛素样生长因子Ⅱ(insulin-like growth factor,IGF-Ⅱ)水平的变化,及其临床意义。方法分析我院2011年4月～2013年2月收治的脑外伤合并骨折患者52例为观察组,单纯骨折患者48例为对照组。检测伤后1、3、7、10、14d的IGF-Ⅱ水平的变化及术后4周、8周、12周骨痂形成率。结果 (1)单纯骨折组伤后1d、3d、7d、10d、14d IGF-Ⅱ水平显著低于脑外伤合并骨折组,差异有统计学意义(P<0.05)。(2)单纯骨折组术后4周、8周、12周骨痂形成率低于脑外伤合并骨折组,差异有统计学意义(P<0.05)。脑外伤合并骨折患者血清IGF-Ⅱ水平显著高于单纯骨折患者,骨痂愈合情况脑外伤合并骨折组显著好于单纯骨折组。结论血清胰岛素样生长因子Ⅱ可能在促进骨折愈合中有一定的作用。
Objective To analyze the clinical significance and changes of the level of serum insulin-like growth factor Ⅱ in brain trauma patients with fracture. Methods Fifty-two cases of brain trauma patients with fracture in our hospital from 2011 April to 2013 February were divided into the observation group and the control group. 48 cases of patients with fracture were divided into the control group. The changes of IGF- Ⅱ levels of two groups of patients after injury were compared on ld,3d,7d,10d,14d, and the callus formation rate after 4 weeks, 8 weeks, 12 weeks. Results （1）The IGF-Ⅱlevels of simple fracture group on ld,3d,7d, 10d, 14d were significantly lower than that of traumatic brain injury fracture group. There were significant statistically between two groups （P 〈 0.05）. （2）The callus formation rate of simple fracture group on 14 weeks, 8 weeks, 12 weeks were significantly lower than that of traumatic brain injury fracture group. There were significant statistically between two groups （P 〈 0.05）. The levels of serum IGF-Ⅱ of brain injury combined with fracture patients were significantly higher in patients with simple fracture. Callus healing in pa- tients of brain injury combined with fracture group was significantly better than a simple fracture group. Conclusion Serum insulin like growth factor Ⅱ in promoting fracture healing has a certain role.
出处
《中国现代医生》
2014年第2期19-20,23,共3页
China Modern Doctor
