摘要
本文通过HPLC-ESI-Q-TOF-MS技术对独活水提取部分中的化学成分进行定性分析,采用LC-MS/MS,C18色谱柱(4.6 mm×250 mm,5μm),以甲醇-0.1%甲酸溶液为流动相梯度洗脱,使用ESI离子源,正离子与负离子模式下采集数据。通过正、负离子质谱信息及元素组成,分析与相关文献数据对照,共鉴定出12个化合物,为阐明独活水提部分的药效物质基础提供有力的证据。
The manuscript make a qualitative analysis on chemical components in water extract of Angelicae Pubescentis Radix by HPLC-ESI-Q-TOF-MS; LC-MS/MS, C 18 （4.6 mm×250mm,5μm） column was adopted, with methanol -0. 1% formic acid as the mobile phase for gradient elution;ESI ion source was used for mass spectra, and data were collected in positive and negative mode. twelve compounds from water extract ofAngelicae Pubescentis Radix were identified by analy- zing positive and negative ion mass spectra information and element composition and comparing controls with data from relevant literature, these provide powerful therapeutic material basis for water extract of Angelicae Pubescentis Radix.
出处
《天然产物研究与开发》
CAS
CSCD
北大核心
2014年第1期69-76,共8页
Natural Product Research and Development
基金
江苏高校优势学科建设工程资助项目(2011ZYX6-014)
江苏省2012年度普通高校研究生科研创新计划项目(CXZZ12-0626)
江苏省中医药局科技项目(LZ13013)
