摘要
目的探讨通过检测代谢综合征患者血清同型半胱氨酸(Hcy)水平,并测定血压及血管硬化主要指标为踝臂指数(ABI)和肱踝脉搏波传导速度(baPWV)。了解患者外周血管硬化程度,分析对比在不同血清同型半胱氨酸水平与其周围血管僵硬度之间的关系,为临床减少心脑血管事件的发生提供临床依据。方法测定代谢综合征患者血清同型半胱氨酸水平,了解患者外周血管硬化程度,如外周血管硬化明显或堵塞,则彩色多普勒进一步明确诊断。结果代谢综合征组,包括高血压高Hcy组(A组)、高血压正常Hcy组(B组)、正常血压高Hcy组(C组)、正常血压正常Hcy组(D组),血浆同型半胱氨酸水平与健康体检者为对照组(E组)比较明显升高,而且A组>C组>B组>D组>E组;而ABI水平则相反,A组<C组<B组<D组<E组,血浆同型半胱氨酸水平越高,则ABI则越低,反映下肢动脉狭窄或阻塞程度越严重。同样的baPWV水平A组<C组<B组<D组<E组,说明全身血管的僵硬度A组>C组>B组>D组>E组,血管弹性A组<C组<B组<D组<E组。代谢综合征组Hcy水平、ABI、baPWV水平与正常对照组显著升高,具有统计学意义(P<0.05)。结论代谢综合征患者血清同型半胱氨酸水平越高,ABI、baPWV水平则越高,周围血管的僵硬度就越明显,发生心脑血管事件的风险越高,具有密切相关性,对患者疾病预防干预及临床病情的评估具有重要指导作用。
Objective To explore the relationship between different serum Hey level and peripheral vascular stiffness in patients of metabolic syndrome, the peripheral vascular stiffness is evaluated by ABI （ankle branchial index） and PWV （pulse wave velocity）, to provide the clinical evidences for cardiovascular and cerebrovascular events decrease. Methods Testing serum Hcy level, understanding artery stiffness degree, such as the significance and blocking of peripheral vascular sclerosis, and doing diagnosis through Color Doppler Ultrasonography. Results Serum Hcy level in patients of metabolic syndrome, including group of hypertension and high Hcy （ group A） , group of hypertension and normal Hcy level（ group B） , group of normal blood pressure and high Hcy level（ group C ） and group of normal blood pressure and normal Hcy level（ group D） , elevates significantly compared with subjects in normal control group （group E） ; moreover, the result is group A 〉 group C 〉 group B 〉 group D 〉 group E. However, ABI level is reverse, with group A 〈 group C 〈 group B 〈 group D 〈 group E. When the serum Hcy level is higher, ABI becomes lower and the peripheral vascular stiffness is more severe. At the same time,PWV level ： group A 〈 group C 〈 group B 〈 group D 〈 group E indicates that vascular stiffness in group A 〉 group C 〉 group B 〉 group D 〉 group E and vascular elasticity in group A 〈 group C 〈 group B 〈 group D 〈 group E. So serum Hcy level, ABI and baPWV are elevated significantly in patients of metabolic syndrome, than that in normal control group （P 〈 0.05 ）. Conclusion The serum Hcy level elevates higher, the ABI and baPWV become higher too, the peripheral vascular stiffness is more severe, and the risk of incidence of cardiovascular and cerebrovascular events is higher. There is significant correlation among them. There is important guiding effect for patients＇ disease pre＋ vention intervention and clinical evaluation.
出处
《黑龙江医学》
2014年第1期36-38,共3页
Heilongjiang Medical Journal
