摘要
目的:评价针刀联合玻璃酸钠膝关节内注射与单纯玻璃酸钠治疗膝骨关节炎(KOA)的临床疗效。方法:以"Osteoarthritis""acupotomy""needle-knife""sodium hyaluronate""膝骨性关节炎""玻璃酸钠""小针刀"等词语检索了Cochrane Library(2013年第二期)及PubMed、CBM、CNKI、VIP、万方、中国生物医学期刊引文数据库,检索时间范围为各数据库建库至2013年05月20日。文献质量评价及RCT(随机对照试验)纳入由两个人员分别独立完成,使用Cochrane Library提供的RevMan 5.2统计学软件进行数据分析。结果:共纳入7篇相关RCT总计583例病人纳入研究,分析结果显示:针刀联合玻璃酸钠膝关节内注射治疗KOA的短期疗优于单纯玻璃酸钠膝关节内注射(OR=4.18,95%CI[2.21,19.21],Z=7.51,P<0.00001)。结论:针刀联合玻璃酸钠膝关节内注射治疗KOA的短期疗优于单纯玻璃酸钠膝关节内注射。但是,鉴于纳入文献的质量较低,且均未记录不良事件,针刀联合玻璃酸钠治疗KOA的疗效是否优于单纯使用玻璃酸钠关节腔内注射尚有待于更多设计严谨的临床试验来论证。
Objective：To assess the efficacy of acupotomy combined with sodium hyaluronate versus sodium hyaluronate a- lone for knee osteoarthritis （KOA）. Methods： Randomized,controlled trials （RCTs） of acupotomy combined with sodium hyaluronate versus only sodium hyaluronate in treating KOA were searched from CNKI, VIP, WanFang, PubMed, CBM and The Cochrane Central Register of Controlled Trials （Issue 2, 2013） with the deadline of retrieval may 20th, 2013. The Cochrane Collaboration＇s RevManS. 2 software was used for meta-analysis for the data which were extracted and evaluated by two reviewers independently. Results： Seven trials involving 583 patients in total were included. The meta-analyses showed that the efficacy of acupotomy combined with sodium hyaluronate was higher than simple sodium hyaluronate in short term （OR=4.18, 95%CI [-2.21, 19. 21], Z=7.51,P〈0. 00001）. Conelusion：Acupotomy combined with sodium hyaluronate is more effective than simple sodium hyaluronate in treating KOA in short term. However, most of the includ- ed studies are of low quality and no reports of adverse events are found, well-designed RCTs are still needed to further eval- uate the efficacy of acupotomoy combined with sodium hyaluronate.
出处
《中国中医骨伤科杂志》
CAS
2014年第2期15-17,20,共4页
Chinese Journal of Traditional Medical Traumatology & Orthopedics
基金
国家中医药管理局"十一五"重点学科建设项目
北京市中医药管理局外治法专项基金(WZF2012-09)
关键词
膝骨关节炎
针刀
玻璃酸钠
META分析
Knee osteoarthritis
Acupotomy
Sodium hyaluronate
Meta-Analysis
