摘要
目的评价国内不同剂量甲泼尼龙在重型手足口病中的疗效。方法计算机检索我国公开发表的有关不同剂量甲泼尼龙治疗重型手足口病的随机对照和病例对照研究,对纳入研究的结局变量通过RevMan5.0软件进行Meta分析。结果纳入的8篇研究共716例患者。分析发现神经系统症状持续时间(OR=-0.80,95%CI:-2.20^-0.60),退热时间(OR=-0.87,95%CI:-1.05^-1.06),住院时间(OR=3.12,95%CI:1.11~5.13),血糖(OR=0.97,95%CI:0.55~1.38),心率(OR=10.83,95%CI:-4.42~6.42),差异均有统计学意义。结论大剂量甲泼尼龙总体治疗效果不优于小剂量甲泼尼龙,治疗中应权衡利弊,酌情应用,而不是盲目的使用大剂量冲击治疗。
Objective To evaluate the efficacy and safety of different doses of methylprednisolone in the treatment of severe hand, foot and mouth disease （HFMD）. Methods Published case-control or random controlled studies of HFMD treated with different doses of methylprednisolone in China were reviewed and analyzed using RevMan 5.0 software for Meta-analysis. Results A total of 716 patients from 8 reported studies were included. Meta-analysis indicated that the duration time of symptoms in the nervous system was at an OR （odds ratio） of-0.80, 95% CI--2.20 to --0.60; antifebrile time was at the OR 0.87, 95% CI--1.05 to -1.06; length of hospitalization was at the OR 3.12, 95% CI 1.11 to 5.13, blood glucose level was at the OR 0.97, 95% CI 0.55 to 1.38, and heart rate was at the OR 10.83, 95% CI -4.42 to 6.42. There were significant differences among all above factors. Conclusions The efficacy of high-dose methylprednisolone was not superior to low-dose; the advantages and disadvantages should be carefully considered when deciding the doses in the treatment of severe HFMD.
出处
《中国病毒病杂志》
CAS
2014年第1期53-57,共5页
Chinese Journal of Viral Diseases
关键词
手足口病
甲泼尼龙
剂量
Hand-foot-and mouth disease
Methylprednisolone
Dose
