摘要
目的探讨血液灌流对维持性血液透析患者难治性高血压的治疗效果。方法维持性血液透析合并难治性高血压患者40例,随机分为常规组与联合组各20例,常规组采取血液透析治疗,联合组采用血液透析+血液灌流治疗;检测2组透析前、后血浆内皮素、肾素、血管紧张素Ⅱ水平,比较2组治疗前、后血压。结果常规组治疗前、后血压、血浆内皮素、肾素、血管紧张素Ⅱ水平差异无统计学意义(P>0.05),联合组治疗后血压、血浆内皮素、肾素、血管紧张素Ⅱ水平均较治疗前明显下降(P<0.01)。结论血液灌流对维持性血液透析难治性高血压患者疗效确切,其治疗作用与血液灌流清除尿毒症患者体内血浆内皮素、肾素、血管紧张素Ⅱ中、大分子物质有关。
Objective To evaluate the effect of hemoperfusion on refractory hypertension in patients with maintenance hemodialysis （MHD）. Methods Forty MHD patients complicated with refractory hypertension were randomly divided into two groups, with 20 patients in each group. HP group received hemodialysis plus hemoperfusion therapy and control group received hemodialysis. The levels of plasma endothelin, renin and angiotensin Ⅱ were detected and blood pressure was compared before and after hemodialysis between two groups. Results The blood pressure, endothelin, renin and angiotensin Ⅱ did not change after treatment in control group （P〉 0.05）, and decreased obviously after treatment compared with those before treatment in HP group （P〈0.01）. Conclusions Hemoperfusion is effective for refractory hypertension in MHD patients, because hemoperfusion could remove macromolecular substances in endothelin, renin and angiotensinⅡ.
出处
《中华实用诊断与治疗杂志》
2014年第2期181-182,共2页
Journal of Chinese Practical Diagnosis and Therapy
关键词
血液灌流
高血压
血液透析
Hemoperfusion
hypertension
hemodialysis
