摘要
目的观察解毒软坚方治疗毒邪内蕴、瘀阻肝络型乙型肝炎后肝硬化的临床疗效。方法将65例患者随机分为治疗组(32例)和对照组(33例),治疗组予解毒软坚方治疗,对照组予鳖甲软肝片治疗。两组疗程均为3个月,观察临床疗效、肝功能及主要症状体征变化情况。结果①治疗组、对照组临床总有效率分别为93.8%和54.5%,组间临床疗效差异有统计学意义(P<0.05)。②治疗前后组内比较,治疗组治疗后各项症状和体征积分差异均有统计学意义(P<0.05);对照组除腹痛、瘀斑外,其余症状和体征积分差异有统计学意义(P<0.05);组间治疗后比较,乏力、腹胀、腹痛、胁胀、失眠、瘙痒积分及总分差异有统计学意义(P<0.05)。③治疗前后组内比较,治疗组ALT、AST、GGT、DBIL、ALB差异有统计学意义(P<0.05),对照组ALT、AST差异有统计学意义(P<0.05);组间治疗后比较,AST、TBIL、DBIL差异有统计学意义(P<0.05)。结论解毒软坚方治疗毒邪内蕴、瘀阻肝络型乙型肝炎后肝硬化具有良好的临床疗效,可明显改善患者的肝功能及临床症状。
Objective To observe the clinical efficacy of ＂Jiedu Ruanjian Formula＂ for the treatment of hepatitis B. Methods Sixty-five cases were randomized into two groups： treatment group in which 32 cases were treated with ＂Jiedu Ruanjian Formula＂, and control group in which 33 cases were treated with ＂ Biejia Ruangan Tablets＂, with the course of 3 months. The clinical efficacy, liver function and main symptoms and signs were observed. Results ① The overall effective rate was 93.8% in the treatment group and 54.5 % in the control group, with a difference between tile two groups（ P 〈 0.05）. ② After treatment, the indexes in treatment group were improved significantly （ P 〈 0.05 ） ; except for abdominal pain and ecchymosis, the other indexes in control group were significantly improved （ P 〈 0.05 ） ; there were significant differences in the scores of fatigue, abdominal distension, abdominal pain, rib-side distention, insomnia and pruritus between the two groups （P 〈 0.05）. ③ In treatment group, there were significant differences in the levels of ALT, AST, GGT, DBIL and ALB between before and after treatment （ P 〈 0.05 ）, and significant differences were found in the levels of ALT and AST in control group between before and after treatment （ P 〈 0.05 ） ; significant differences were found in the levels of AST, TBIL and DBIL between the two groups （ P 〈 0.05 ）. Conclusion ＂＇ Jiedu Ruanjian Formula＂ has positive effect on hepatitis B cirrhosis, and can improve the liver function and clinical symptoms.
出处
《上海中医药杂志》
2014年第2期31-34,共4页
Shanghai Journal of Traditional Chinese Medicine
基金
上海市卫生局资助项目(2010S25)
上海市中医药事业发展三年行动计划"研究型中医院建设"项目(ZYSNXD-CC-YJXYY-JS13)
关键词
乙型肝炎
肝硬化
毒邪内蕴
瘀阻肝络
解毒软坚方
hepatitis B
cirrhosis
inner poisonous pathogenic factor
stasis obstructing the liver
＂Jiedu Ruanjian Formula＂
