摘要
目的探讨抑郁症患者儿茶酚胺氧位甲基转移酶(COMT)基因Val108/158Met多态性与改良性电抽搐治疗疗效的关系。方法采用病例对照研究方法,选取目前符合《中国精神疾病分类与诊断标准》中抑郁发作标准的患者100例入研究组,接受8次MECT治疗,同时筛选正常对照者100名。运用聚合酶链式反应检测两组COMT(rs4680)基因分型多态性,同时研究组使用汉密尔顿抑郁量表(HAMD)在入组时及每次MECT治疗后评定患者抑郁严重程度及疗效,统计分析比较不同COMT基因型与MECT治疗后HAMD评分的关系。结果①MECT治疗抑郁症的疗效显效率是100%,痊愈率是32.3%;②研究组A等位基因频率为29%,对照组为43.5%;研究组G等位基因频率为71%,对照组为56.5%,两组差异具有统计学意义(P<0.01);③第四次治疗后的有效率G/G基因型为45%,A/G基因为7%;第六次治疗后的有效率G/G基因型为60%,A/G基因型为17%,差异有统计学意义(P<0.01)。结论①MECT治疗抑郁发作疗效好;②研究组COMT基因型与正常组有差异;③COMT基因型为G/G和A/G的患者对MECT治疗更敏感。
Objective To explore the correlation between COMT gene Val^108/158 met polymorphism in depression patients and the effect of modified electroconvulsive therapy （MECT）. Methods 100 patients matching the depressive episode criteria of Chinese Classification and Diagnostic Criteria of Mental Disorders were chosen as the research group, and received MECT 8 times, at the same time 100 patients were screened as the normal control. PCR was used to measure COMT （rs4680） genotyping polyrnorphism in the two groups, meanwhile Hamilton depression rating scale （HAMD） was used to evaluate the patients＇ depression severity and the curative effect at enrollment or after each MECT in the research group, with statistical analysis and comparison the relation between COMT genotypes and HAMD scores after each MECT. Results： ① MECT showed 100% efficiency in treating depression, the recovery rate was 32.3%; ②A allele frequency was 29% in the research group, and was 43.5% in the control group; G allele frequency was 71% in the research group, and was 56.5% in the control group, with statistical significant difference between the two groups （P〈0.01）; ③ The efficacy of G/G genotype was 45% after the fourth treatment, and A/G genotype was 7%; the efficacy of G/G genotype was 60% after the sixth treatment, A/G genotype was 17%, with statistical significant difference （P〈0.01）. Conclusion ① MECT is effective in the treatment of depressive episode; ② COMT genetypes are different between the research group and the normal group; ③ Patients with COMT genotypes as G/G and A/G are more sensitive to MECT.
出处
《临床医学工程》
2014年第2期136-138,共3页
Clinical Medicine & Engineering
基金
广州市医药科技基金项目(项目编号:20112131260208)
关键词
改良电抽搐治疗
抑郁障碍
儿茶酚胺氧位甲基转移酶基因
Modified electroconvulsive therapy （MECT）
Depressive disorder
Catechol-O-methyltransferase （COMT） gene
