摘要
目的探讨手术治疗前后直肠癌患者血清中CEA、HCY、TGF-β1水平的变化及临床意义。方法采用放免法(RIA)、酶联法(ELISA),检测了33例手术治疗前后直肠癌患者血清中CEA、HCY、TGF-β1的水平,和正常人组(35例)的相关指标进行比较。结果术前直肠癌患者血清CEA、HCY、TGF-β1的水平与正常对照组比较,差异有非常显著性(P<0.01),术后半年,未复发者(29例)血清CEA、HCY、TGF-β1的水平持续下降,接近正常人,复发者(4例)的相关指标水平再次上升,与术前水平接近,明显的较未复发者高,2组差异有非常显著性(P<0.01)。并且血清中CEA的水平与HCY、TGF-β1的水平呈显著正相关(r=0.6018 0.5988,P<0.01)。结论检测手术治疗前后直肠癌患者血清CEA、HCY、TGF-β1水平变化对了解病情、观察疗效和判断预后具有重要的临床指导意义。
Objective To explore the serum CEA,HCY,and TGF-β1 level changes before and after surgical treatment of rectal cancer and the clinical significance .Methods Serum CEA,HCY,and TGF-β1 levels of 33 rectal cancer patients were detected before and after surgery using radiation immunity analysis （RIA） and enzyme-linked method（ELISA）, and the results were compared with the related indexes of a normal group （35 cases）.Results Before operation, serum CEA,HCY,and TGF-β1 levels of the patients with rectal cancer ,compared with the normal group , demonstrated a highly significant difference （P〈0.01）.Half a year after operation,serum CEA,HCY,and TGF-β1 levels of those with no relapse （29 cases） kept decli-ning to levels close to the normal .The related indexes of those who relapsed （4 cases） rose again,approaching preoperative levels, remarkably higher than those without relapse .There was a significant difference （P〈0.01）,and serum CEA level and HCY,TGF-β1 levels showed significantly positive correlation （r=0.6018,0.5988,P〈0.01）.Conclusion It is of important clinical significance to test serum CEA ,HCY,TGF-β1 level changes before and after surgical treatment of patients with rectal cancer for understanding the patients＆#39;situation, observing the curative effect and predicting the prognosis .
出处
《淮海医药》
CAS
2014年第2期135-136,共2页
Journal of Huaihai Medicine
关键词
直肠肿瘤
癌胚抗原
同型半胱氨酸
转化生长因子-Β1
Rectal cancer
Cancino-embryonic antigen （ CEA ） Homocysteine （ HCY ） Transforming growth factor-β1 （ TGF-β1 ）
