摘要
目的:比较开腹与腹腔镜大肠癌手术前后患者内皮素(ET)、一氧化氮(NO)、白细胞介素-6(IL-6)以及C-反应蛋白(CRP)的变化情况。方法:将80例大肠癌患者随机分为开腹组与腹腔镜组,各为40例。比较两组手术前后ET、NO、IL-6及CRP的变化情况。结果:(1)开腹组术后第1、2天ET水平均小于腹腔镜组术后第1、2天,差异具有统计学意义(P<0.05);(2)开腹组手术结束时、术后第1、2天NO水平与手术开始时相比,差异均具有统计学意义(P<0.05),腹腔镜组手术结束时、术后第1天与开始时相比,差异均具有统计学意义(P<0.05),且两组在术后第2天时NO水平比较,差异具有统计学意义(P<0.05);(3)开腹组手术结束时、术后1、2、3天IL-6水平与开始时相比,差异均具有统计学意义(P<0.05),而腹腔镜组手术前后IL-6水平相比,差异均具有统计学意义(P<0.05),且两组术后IL-6水平比较,差异均具有统计学意义(P<0.05);(4)两组术后CRP水平与手术开始时相比,差异均具有统计学意义(P<0.05),且开腹组术后CRP水平均小于腹腔镜组,差异均具有统计学意义(P<0.05)。结论:腹腔镜下大肠癌手术对应激相关细胞因子影响小,比开腹手术应激反应轻、强度低以及持续时间短。
Objective. To compare changes of ET, NO, IL-6 and open and laparoscopic eolorectal surgery. Methods. Totally 80 patients CRP before and after undergoing with colorectal cancer were ran- domly divided into laparotomy group and laparoscopic group according to balloting method with 40 cases in each group. Changes of ET, NO, IL 6 and CRP were compared before and after undergoing the surgery.Results： （1） ET.. on the 1st and 2nd day, ET of the laparoscopie group after surgery were significantly lower than those of laparoscopic group （P^0.05）. （2） NO： There were statistical differences in NO lev- els between the ends of surgery, on the first and second day, and at the beginning of the surgery in the laparoscopic surgery group （P d0.05） ; there were significant differences in NO levels between the ends of surgery, on the first and second day, and the beginning of the surgery in the laparotomy group （P~ 0.05） ,on the 1st and 2nd day, NO levels were significantly lower than those of the laparoscopic surgery group （P^0.01）; （3） II.-6： There were statistical differences in II.-6 level between the ends of laparo- scopic surgery, 1,2,3 days and the beginning of surgery in the Iaparoscopic surgery group （P^0.05）. There were significant differences in IL-6 levels of the laparotomy group before and after surgery （P~ 0.05） ,and the end of laparoscopic surgery, postoperative IL6 were significantly lower than that of the iap- arotomy group （P^0.05） ; （4） CRP levels showed significant differences after undergoing surgery compa- ring with that at the beginning of the surgery in both groups （P^0.05）, and CRP of the laparoscopic group were significantly lower than the laparotomy group （P^0.05）. Conclusions： Laparoscopic colorec tal surgery shows smaller influence on stress-related cytokines, its intensity is smaller, intensity is lighter and its duration is shorter than laparotomy surgery.
出处
《海南医学院学报》
CAS
2014年第4期497-500,共4页
Journal of Hainan Medical University
基金
湖北省荆州市科技局基金(201283723)~~
