期刊文献+

寡肽转运蛋白(PepT1)生物学特性及活性调控研究进展

Progress of the Biological Characteristics and Activity Regulation of Oligo Peptide Transporters(Pept1)
下载PDF
导出
摘要 作为蛋白质主要的消化产物,小肽的吸收不仅在氨基酸消化、吸收和代谢中起到至关重要的作用,对于维持反刍动物的生长、发育也具有重要意义。目前寡肽转运蛋白(PepT1)被预测出有12个跨膜结构域,Fei等对其跨膜结构域进行了初步的研究。PepT1所具有的无从差别转运小肽、在特定的PH条件下电现象等特点也使得其成为学者们研究的热点。此外,底物因素、生理生物因素以及营养因素等对于PepT1活性调控的影响也是人们研究的热点。本文基于对PepT1生物学特性及活性调控研究进展的论述,对PepT1的研究前景进行了展望,以期为促进PepT1的进一步研究提供进一步的参考。 As the main digestive products of protein, the small peptide absorption not only is of significance in digestion, absorption and metabolism of amino acids, but also plays a crucial role in the maintenance of the ruminant growth and development. Currently, oligo peptide transporters (Pep T1 ) was predicted to have 12 transmembrane domains, which had been studied. As the PepT1 had several characteristics, such as the indiscriminate transport and its electricity phenomenon under the condition of certain pH, and thus it had become a hot spot. In addition, the substrate factors, physiological and biological factors and the influence of nutritional factors for PepT1 activity regulation was also hot spot. In this paper, the progress on biological characteristics and activity of PepT1 regulation was described, which would provide further information for studying the Pep T1.
作者 王建锦 陈宏
出处 《中国牛业科学》 2014年第1期33-36,共4页 China Cattle Science
基金 现代农业(肉牛)产业技术体系专项(CARS-38) 陕西省农业科技创新项目(2012NKC01-13) 江苏高校优势学科建设工程资助项目
关键词 小肽转运蛋白 生物学特性 活性调控 small peptide transporters (Pept 1 ) , biological characteristics activity regulation
  • 相关文献

参考文献6

二级参考文献70

  • 1郑云峰,许云英,徐玉娟.蛋白质营养中小肽的研究新进展[J].饲料研究,2006,29(2):7-9. 被引量:5
  • 2胡梦红,王有基,熊邦喜.小肽的吸收机制及其对鱼类的营养生理学效应[J].长江大学学报(自科版)(中旬),2007,4(1):39-44. 被引量:14
  • 3范淳,陈代文,余冰,杨玫.小肽转运载体(PepT1和PepT2)研究进展[J].饲料工业,2007,28(1):11-15. 被引量:4
  • 4熊钢.鲫鱼LATZ和PEPT1基因克隆、序列分析及组织表达研究:[硕士学位论文][D].湖南:湖南农业大学,2010.
  • 5Amberg J,Camisaka Y,Kamisaka Y,et al.Expression of the oligopepdde transporter PepT1 in larval Atlantic cod (Gadus morhua)[J].Comp Biochem PHysiol B Biochem Mol Biol,2008,50(2) :177-182.
  • 6Bakke N,Ann E,Olderbakk J,et al.Dietary protein hydrolysates and free amino acids affect the spatial expression of peptide transporter PepT1 in the digestive tract of Adantic cod(Gadus morhua)[]].Comparative Biochemistry and Physiology,2010,156:48-55.
  • 7Daniel H.Molecular and integrative pHysiology of intestinal peptide mansport[J].Annu Rev PHysiol,2004,66:61-84.
  • 8Kottra G,Stamfort A,Daniel H.PepT1 as a paradigm for membranecarriers that mediate electrogenic bidirectional transport of anionic,cationic,and neutral substrates[J].J Biol Chem,2002,277(326):83 - 91.
  • 9Leibach F H,Ganapathy V.Peptide transporters in the intestine and the kidney [J].Annu Rev Nutr, 1996,16,99 - 119.
  • 10Mafia M,Rizzello A,Acierno R,et al.Haracterisadon of intestinal peptide transporter of the Antarctic haemoglobiniess teleost Chionodraco hamams [J].J Exp Biol,2003,206(4) :705 - 714.

共引文献30

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部