摘要
目的评价持续气道正压通气对OSAHS患者外周血炎症因子IL-6的影响。方法计算机检索CochraneLibrary、Embase、PubMed、中国学术期刊全文数据库、万方数据库并手工检索相关期刊，全面收集持续气道正压通气（CPAP）对OSAHS外周血IL-6影响的临床研究，照纳入、排除标准选择试验并评价质量，而后提取有效数据．应用R软件进行Meta分析。结果最终纳入21篇文献．包括635例患者。Meta分析结果显示各研究问有异质性（P=0．000；I2=95．5％）。经CPAP治疗后，IL6明显降低，随机效应模型：SMD=1．57，95％（0．94，2．19），P〈0．001；固定效应模型：SMD：0．95，95％（0．82，1．08）。P〈O．001。结论现有临床研究证据显示，CPAP治疗能明显减轻OSAHS患者外周血中IL-6。但因研究质量普遍不高，因此期待开展更多的多中心、大样本、长期随访的随机双盲对照试验深入验证。
Objective To evaluate the impact of continuous positive airway pressure （CPAP） on interleukin 6 （IL-6） in peripheral blood of obstructive sleep apnea hypopnea syndrome （OSAHS）. Methods The clinical trials involving CPAP on IL-6 in OSAHS were searched and identified from Cochrane Library, Embase, PubMed, China Academic Journals Fulltext database, Wanfang database. According to inclusion and exclusion criteria and to evaluate the quality of choice experiment, and then extract the valid data for meta-analysis by R software. Results We included 21 articles, including 635 patients. Meta-analysis showed there had significant heterogeneity between studies of （ P =0. 000; I2= 95.5%）. After CPAP treatment, IL-6 was significantly lower in random effects model：[SMD：l. 57,95 （0. 94,2. 19）, P 〈0. 001] and in fixed effects model： [SMD： 0. 95, 95% （0.82, 1.08）, P 〈0. 001]. Conclusions Existing clinical research evidence, （;PAP treatment can significantly reduce the IL-6 in peripheral blood of patients with OSAHS. However, the quality of research is generally not high, so expect to carry out more multi-center, large sample, long-term follow-up of randomized, double blind, controlled trial to confirm.
出处
《国际呼吸杂志》
2014年第3期191-195,共5页
International Journal of Respiration
