摘要
目的:探讨检测类风湿关节炎患者体内抗环瓜氨酸多肽(CCP)水平在病情诊断过程中的临床应用价值。方法:选取类风湿关节炎患者80例,其他类别结缔组织疾病患者80例以及同期接受体检的健康人群80例为研究对象,采用酶联免疫吸附法对三组血清中抗CCP抗体滴度进行检测,并检测类风湿关节炎患者、其他类别结缔疾病患者以及健康人群体内IgM-RF阳性表达率,并对类风湿关节炎诊断过程中抗CCP抗体的特异度进行计算。结果:与其他类别结缔疾病患者以及健康人群相比,类风湿性关节炎患者血清中抗CCP抗体阳性表达率明显更高,差异有统计学意义(P<0.05);在本次80例健康体检人群中,78例抗CCP抗体检测为真阴性,余2例为假阳性,抗CCP抗体特异性为97.5%;健康体检人群中抗CCP抗体假阳性率2.5%,明显低于IgM-RF假阳性率21.3%,差异有统计学意义(P<0.05)。结论:在诊断类风湿关节炎过程中,抗CCP抗体特异度极高,其滴度与其他结缔组织疾病患者以及健康人群相比明显更高,具有较高的临床诊断价值。
Objective： To investigate the clinical application value of anti-cyclic levels in diagnosis of patients with rheumatoid arthritis.Method： Selected 80 patients with rheumatoid arthritis, 80 patients with other kinds of connective tissue disease, and 80 cases of healthy people accepted medical examination at the same period for the study.Enzyme-linked immunosorbent method of three groups of serum anti CCP antibody were tested, and tested the IgM -RF positive expression rate of patients with rheumatoid arthritis and other category connective disease patients and healthy people, and calculated the CCP antibody specificity in the process of rheumatoid arthritis diagnosis.Result： Compared to patients with other kinds of connective tissue disease and cases of healthy people, the CCP antibody positive expression rate of rheumatoid arthritis patients was significantly higher（P〈0.05）; In 80 cases of healthy people, 78 cases of anti CCP antibody testing was true negative, 2 cases of false positives, anti-CCP antibodies specificity of 97.5%; The rate of false positives of healthy people was 2.5%, significantly lower than the IgM-RF false positive rate for 21.3%, the differences were statistically significant （P〈0.05）.Conclusion： In the process of diagnosis of rheumatoid arthritis, anti-CCP antibody specificity is extremely high, the titer in patients with other connective tissue diseases as well as a significantly higher compared to healthy subjects, with a high clinical value.
出处
《中外医学研究》
2014年第2期57-58,共2页
CHINESE AND FOREIGN MEDICAL RESEARCH
