摘要
采用不同剂量敌鼠钠分别对SD妊娠大鼠和雄性大鼠一次性灌胃给药 ,观察敌鼠钠对大鼠的抗生育作用。结果表明 ,( 1 ) 5 0 0、2 50和 1 2 5mg/kg体重的敌鼠钠使妊娠大鼠活胎率显著下降 (P <0 0 1 ) ;( 2 )敌鼠钠致死胎的半数有效剂量 (ED50 )为 ( 1 60 2± 0 67)mg/kg体重 ;( 3)形态学观察表明 ,敌鼠钠导致雄性大鼠睾丸曲细精管管壁萎缩、变形并明显变薄 ,致使精母细胞、精子细胞和精子损伤 ,生精细胞层和精子层厚度明显变薄。提示敌鼠钠对雌性及雄性大鼠均有一定的抗生育作用。
In this present study, the effects of anti fertility of Diphacine Na on the pregnancy rats and the males were investigated. The results are as follows: (1) Compared with control group, the ratio of live fetus of the high dose groups, such as 5 0, 2 5 and 1 25?mg/kg were markedly decreased( P <0 01);(2) The half effective dose ( ED 50 ) of Anti pregnancy was measured to be (1 602±0 676)?mg/kg;(3) The morphological examinations indicated that Diphacine Na caused testicular lesion in contrast with that of the control group. Spermatozoa, spermatid and spermatocytes in seminiferous tubules were mainly damaged. Meanwhile the wall of seminiferous tubules became atrophy, deformities and thin obviously. These results suggest that Diphacine Na has anti fertility effect on rats.
出处
《动物学杂志》
CAS
CSCD
北大核心
2001年第1期35-38,共4页
Chinese Journal of Zoology
基金
浙江省科技计划项目! (No.98110 2 311)
