摘要
目的探讨孕早期高蛋白质膳食(HPD)对子代肥胖和肉碱酰基转移酶1(CPT1)表达的影响,寻找肥胖防治的靶标和合理的孕期膳食。方法孕早期大鼠分别给予HPD和标准膳食(SD),其后代分别为高蛋白质组(HP)和对照组(CON),SD喂养至成年,高脂膳食诱导肥胖,FQ-PCR法检测CPT1mRNA的水平。结果与对照组相比,HPD大鼠子代的体重持续降低(P<0.05),CPT1 mRNA水平持续升高。结论孕早期HPD可通过程序性升高子代CPT1 mRNA的水平,降低肥胖的发生。
Objective To study the effects of high protein diet（HPD） during early pregnancy on offspring carnitine acyltransferase 1 （CPT1） mRNA, and find out optimal pregnant diet. Methods Rats were fed with a HPD and standard diet （SD） during early pregnancy, respectively. Male offspring were high protein （HP） and control （CON） group, respectively. Offspring were fed with a SD until adult. Rats were fed with high fat diet to induce obesity. CPT1 gene was analyzed by FQ-PCR. Results Body weight were decreased and CPT1 mRNA were increased in HP group （P＆lt;0.05）. Conclusion HPD during early pregnancy can prevent offspring from obesity by mediating lipolysis.
出处
《中国实用医药》
2013年第36期29-30,共2页
China Practical Medicine
基金
黑龙江省教育厅面上项目(项目编号:12531795)
