摘要
目的探讨大学生新生乙肝疫苗无应答者加强接种的免疫效果的影响因素。方法以某学院新入学的学生为对象,选择乙肝五项全阴者86人,分为两组,分别用20μg×3剂量和0、1、3个月接种程序进行复种,并对接种成功率进行统计分析。结果通过改变接种时间间隔复种乙肝疫苗,其抗-HBs阳性率为32.6%;用20μg剂量乙肝疫苗接种抗-HBs阳性率达90.7%,两组相比具有统计学意义(P<0.001)。结论采用20μg乙肝疫苗并按程序接种对无应答者能发挥较好的免疫效果。
Objective To explore the relationship between success rate of hepatitis B vaccination and vaccine dose in the college freshers. Methods The freshmen of certain college,86,were selected as observation object.Students with all negative five items of hepatitis B were divided into the group I and II.The group I received the vaccine with a dose of 20μg＆#215;3 and the group II with 0,1,3 vaccination program for replanting. The success rate of hepatitis B vaccination of the college freshers was calculated.Results The positive rate of HBs-Ab was 32.6%after revaccination of HBV vaccine with 0,1,3 program. The positive rate of HBs-Ab was 90.7%with a dose of 20μg＆#215;3,the difference between the two groups was statistically significant （P＆lt;0.001） . Conclusion It is an optimal scheme for non-responders to be inoculated with a dose of 20μg＆#215;3.
出处
《当代医学》
2014年第5期158-159,共2页
Contemporary Medicine
基金
河南省教育厅自然科学研究计划项目(2008C 310002)
关键词
乙肝疫苗
无应答
接种剂量
HBV vaccine
Non-response
Choice of dose
