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线粒体异常与帕金森病相关性 被引量：4

Correlation between mitochondrial dysfunction and the pathogenesis of Parkinson's disease
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摘要 帕金森病为中枢神经系统退行性疾病。尽管其确切的发病机制尚不清楚,但近年来越来越多的研究表明线粒体异常是帕金森病发病的关键。本文主要从线粒体动态变化、线粒体自噬、线粒体DNA突变,以及线粒体复合物Ⅰ抑制等方面对线粒体异常与帕金森病发病的相关性进行概述。 Parkinson＇s disease （PD） is a progressive neurodegenerative disease. A growing number of studies have shown that mitochondrial dysfunction plays an important role in the pathogenesis of PD. Therefore, this review will mainly discuss the research progress on the correlation between PD and abnormal mitochondrial dynamics, mitochondrial autophapy as well as mitochondrial DNA mutations and mitochondrial complex I inhibition.
作者 刘小钰 丁健青
机构地区 上海交通大学医学院附属瑞金医院神经科
出处 《中国现代神经疾病杂志》 CAS 2014年第2期129-133,共5页 Chinese Journal of Contemporary Neurology and Neurosurgery
基金 国家自然科学基金资助项目(项目编号:81371408)~~
关键词 帕金森病 线粒体 自噬 DNA 线粒体 综述 Parkinson disease Mitochondria Autophagy DNA, mitochondrial Review
分类号 R742.5 [医药卫生—神经病学与精神病学]
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参考文献8

二级参考文献136

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共引文献122

同被引文献51

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中国现代神经疾病杂志
2014年 第2期

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