摘要
肝郁脾虚证是抑郁症常见证型之一,常由肝气郁结证转化而来。目前,对于抑郁症肝郁脾虚证的基础研究,一般认为,肝郁脾虚时,机体存在神经—内分泌—免疫系统失调、脑肠轴异常、脑电生理功能紊乱。抑郁症肝郁脾虚证临床治疗的效应机制可能与神经—内分泌—免疫网络、信号通路、基因表达关系密切。该文将近十年有关抑郁症肝郁脾虚证临床流行病学调查、证候标准化研究、病理生理学基础、临床效应及效应机制方面的研究成果及文献进行综述,并对研究中存在的一些问题进行讨论,提出今后的研究思路与建议。
Liver stagnation and spleen deficiency syndrome is one of the common syndromes of depression,which is generally transformed from the syndrome of stagnation of liver qi. So far,the basic research on depression due to liver stagnation and spleen deficiency generally acknowledged that when liver stagnation and spleen deficiency comes up,the following phenomena appear： the imbalance in the body’s nerve-endocrine-immune system,the abnormality of the brain gut axis as well as the dysfunction of EEG. The effector mechanism of clinical treatment of liver stagnation and spleen deficiency syndrome of depression is probably closely related to neural-endocrine-immune network,signaling pathway as well as gene expression. This paper presents comprehensively research achievements and literature on depression due to liver stagnation and spleen deficiency syndrome in clinical epidemiological investigation standardization of syndromes,pathophysiological basis,clinical effect and effect mechanism in recent decade,At last,we discussed the problems existing in the research,and put forward ideas and suggestions for future study.
出处
《环球中医药》
CAS
2014年第2期146-150,共5页
Global Traditional Chinese Medicine
基金
国家自然科学基金(81072717)
关键词
抑郁症
肝郁脾虚
综述
Depression
Liver stagnation and spleen deficiency
Review
