摘要
大多数体内寄生虫的生存必须依赖糖酵解途径将葡萄糖代谢为乳酸以提供能量。乳酸脱氢酶(lactate dehydrogenase,LDH)是糖酵解途径的末端酶,催化丙酮酸还原为乳酸及乳酸氧化为丙酮酸的可逆反应,与寄生虫生存密切相关。研究表明,各种寄生虫LDH在理化性质和分子结构方面均有独特的特性,是良好的诊断分子和潜在的药物作用靶标。对寄生虫LDH功能的研究,对于促进寄生虫病诊断、疫苗研究以及新抗虫药物的研发具有重要意义。本文对国内外寄生虫LDH的研究现状进行了综述。
The survival of most parasites mainly depends on the glycolytic pathway, in which glucose is metabolized to lactic acid for their energy generation. Lactate dehydrogenase （LDH） as a terminal enzyme on anaerobic glycolytic pathway catalyzes the reversible reaction of pyruvate reduction to lactate and lactate oxidation to pyruvate. Thus LDH is closely associated with parasitic survival. Previous studies have showed that LDHs from different parasites exhibit particular physicochemical properties and molecular structures and play as ideal potential targets for diagnosis and drug screening. Research on LDH functions would provide useful information on searching potential antigen candidates for diagnostics and vaccine and on screening therapeutic drugs for parasitic diseases.
出处
《中国动物传染病学报》
CAS
2014年第1期80-86,共7页
Chinese Journal of Animal Infectious Diseases
基金
国家自然科学基金(31272557)
关键词
乳酸脱氢酶
寄生虫
诊断
药物靶标
疫苗
Lactate dehydrogenase
parasites
diagnosis
drug target
vaccine
