摘要
目的:观察疏肝健脾止痢方联合金双歧、畅美治疗溃疡性结肠炎的疗效。方法:146例溃疡性结肠炎患者随机分为观察组和对照组各73例。对照组给予口服金双歧及畅美,观察组给予中药疏肝健脾止痢方,并且联合金双歧及畅美。分析治疗前后的临床症状积分、内镜分级与结肠炎性反应评分。结果:治疗组总有效率95.9%,对照组82.2%。2组比较,差异有显著性意义(P<0.05)。治疗后2组排便次数、粪便性状、血便、腹痛评分均显著低于治疗前(P<0.05);在排便次数、粪便性状、腹痛3项指标上,观察组的评分显著低于对照组(P<0.05)。治疗后2组内镜分级和炎性反应评分均显著减小(P<0.05),观察组的两项评分均显著低于对照组(P<0.05)。随访期间患者均未出现肝肾功能损伤,对照组5例复发腹泻,治疗组无复发。结论:中药疏肝健脾止痢方联合金双歧及畅美治疗溃疡性结肠炎的疗效明显并且稳定,可有效抑制结肠炎性反应。
Objective： To investigate the curative effect of Shugalt Jianpi Zhili Decoction combined with Golden Bifid and OIsalazine Sodium Capsules on ulcerative colitis. Methods： One hundred and forty-six ulcerative colitis patients were evenly and randomly divided into control group and observation group. The control group received Golden Bifid and Olsalazine Sodium Capsules, and the observation group was given Shugan Jianpi Zhili Decoction combined with Golden Bifid and Olsalazine Sodium Capsules. Before and after treatment, we calculated and compared the clinical symptom scores, endoscopic grading and colonic inflammatory reaction scores. Results： The total effective rate of observation group was 95.9% , significantly higher than 82.2% in the control group（P 〈 0.05）. After treatment, the scores of defecation frequency, stool characteristics, bloody stool and stomachache in both groups were significantly lower than those before treatment, and the scores of defecation frequency, stool characteristics and stomachache in the observation group were lower than those in the control group （P 〈 0.05）. The endoscopic grading and colonic inflammatory reaction scores in both groups were significantly lower than those before treatment, and the grading and scores of observation group were lower than those in the control group（P 〈 0.05）. The results of follow-up showed that no hepatic or renal function injury was found in both groups, but diarrhea occurred in 5 patients of the control group. Conclusion： Shugan Jianpi Zhili Decoction combined with Golden Bifid and Olsalazine Sodium Capsules is effective and safe for the treatment of ulcerative colitis, and the mechanism may be related with the inhibition of colonic inflammatory reaction.
出处
《新中医》
CAS
2014年第3期71-73,共3页
New Chinese Medicine
