摘要
目的观察增殖诱导配体(APRIL)在喉鳞癌(LSCC)中的表达。方法采用免疫组织化学SABC法检测150例喉鳞癌患者中癌旁喉黏膜组织、癌组织中是否有APRIL的表达及APRIL的表达量与临床指标之间的关系。结果 APRIL在癌旁喉黏膜组织及癌组织中的阳性表达率分别为6.7%(10/150)、89.3%(134/150),在喉鳞癌不同的TNM分期中随着分期的增进APRIL的表达量逐渐增加且差异有统计学意义(P<0.05),APRIL的表达量与TNM分期相关(P<0.05)。结论 APRIL蛋白在喉鳞癌中高表达,且在不同TNM分期之间差异有统计学意义。
Objective To investigate the expression of a proliferation-inducing ligand（APRIL） in laryngeal squamous cell carcinoma（LSCC）. Methods Expression of APRIL was detected in 150 laryngeal squamous cell carcinoma sam- ples and 150 para-carcinoma tissue by SABC immunohistochermical method. The relationship between APRIL expres- sion and the clinical staging of LSCC was analyzed. Results Expression of APRIL protein in para-carcinoma tissue was 6.7 % （10/150） but 89.3 % （134/150） in tumor tissues. The weighted scores of APRIL in different stages of LSCC were gradually and significantly increased（ P 〈 0.05 ）, APRIL expression level was closely associated with TNM stage （ P 〈 0.05 ）. Conclusion These findings suggest that the APRIL expression are high in LSCC and significantly correla- ted with tumor staging.
出处
《山东大学耳鼻喉眼学报》
CAS
2014年第1期14-16,共3页
Journal of Otolaryngology and Ophthalmology of Shandong University
关键词
喉肿瘤
增殖诱导配体
免疫组织化学
Laryngeal neoplasms
A proliferation-inducing ligand
Immunohistochemistry
