摘要
microRNAs(miRNAs)是真核生物中一类小分子非编码单链RNA,在转录后水平上调控靶mRNA的表达。目前,miRNA功能学研究发现miRNA与胃癌的侵袭转移、化疗耐药、放疗增敏、血管形成、基因甲基化、诊断和预后有直接关系,提示miRNA有可能成为肿瘤治疗的新思路。本文将阐述miRNA和胃癌放化疗的关系及其作为诊断、预后因子和基因治疗靶点基础研究方面的新进展。
MicroRNAs （miRNAs） are a class of small non-coding RNA that regulate their target gene expression at the post- transcriptional level. Functional study of miRNAs have shown that miRNAs have significant effect on chemotherapy resistance, radiother- apy sensibilization, angiogenesis, gene methylation, diagnosis and prognosis in gastric cancer. MiRNAs may shed new lights on the therapy for gastric cancer. This review will elaborate fundamental research of miRNAs in the chemoradiotherapy, diagnosis and progno- sis of gastric cancer.
出处
《临床肿瘤学杂志》
CAS
2014年第1期90-94,共5页
Chinese Clinical Oncology
