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胃癌患者血浆凝血酶激活的纤溶抑制物水平及临床意义 被引量:8

Plasma thrombin-actived fibrionolysis inhibitor level in gastric cancer and their clinical significances
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摘要 目的探讨凝血酶激活的纤溶抑制物活性(TAFI:A)和凝血酶-抗凝血酶复合物(TAT)水平与不同分期胃癌之间的关系。方法收集48例临床胃癌患者、34例同期住院的胃良性疾病患者和50名健康体检者的血液标本,采用发色底物法检测血浆中TAFI水平;ELISA法检测TAT水平;同时检测D-二聚体、纤维蛋白原,分析以上指标在不同分期胃癌的水平。通过受试者工作特征曲线(ROC曲线)分别评价TAFI和TAT的检验效能和最佳诊断分界值。结果与健康对照组及胃良性疾病组相比,胃癌病例组血浆TAFI、TAT、D-二聚体及纤维蛋白原水平均显著升高(P<0.05);胃良性疾病组与健康对照组上述指标的差异则无统计学意义(P>0.05)。血浆TAFI水平为28.85μg/mL时,灵敏度和特异性分别是0.646和0.869;TAT水平为31.50 ng/mL时,灵敏度和特异性分别是0.813和0.786。结论胃癌患者血浆TAFI和TAT水平显著升高是胃癌患者血栓形成倾向的标志,TAFI和TAT有望成为胃癌患病风险的预测指标。 Objective To explore the correlation between different stages of gastric cancer and the levels of thrombin- activated fibrinolysis inhibitor (TAFI) and thrombin-antithrombin (TAT). Methods Blood samples were collected from 48 patients with gastric cancer (gastric cancer group), 34 patients with benign gastric disorders (benign gastric disorder group), and 50 healthy individuals (healthy control group). Plasma levels of TAFI, TAT, D-D and fibrino- gen were measured using a chromogenic substrate method and ELISA. Then their correlations with different stages of gastric cancer were analyzed. The power of test and the best diagnostic value of TAFI and TAT were evaluated with receiver operating characteristic curve ( ROC curve). Results Compared with healthy control group and benign gastric disorder group, the gastric cancer group had higher TAFI, D-D, fibrinogen, and TAT levels ( P 〈 0.05 ). When TAFI level was 28.85 μg/mL, the sensitivity and specificity was 0.646 and 0. 869, respectively. When TAT level was 31.50 ng/mL, the sensitivity and specificity was 0. 813 and 0. 786, respectively. Conclusion Patients with gastric cancer have significantly higher TAFI and TAT levels. TAFI and TAT are indicators of thrombosis tendency, which can be used to evaluate the risk of gastric cancer.
出处 《山东大学学报(医学版)》 CAS 北大核心 2014年第2期73-77,共5页 Journal of Shandong University:Health Sciences
基金 济南市高校自主创新计划(201303048)
关键词 凝血酶激活的纤溶抑制物 凝血酶一抗凝血酶复合物 纤维蛋白溶解 胃癌 Thrombin-activated fibrinolysis inhibitor Thrombin-antithrombin complex Fibrinolysis Gastric cancer
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参考文献26

  • 1Heit J A, Silverstein M D, Mohr D N, et al. Risk factors for deep vein thrombosis and pulmonary embolism: a pop- ulation-based case-control study I J 1. Arch Intern Med, 2000, 160(6) :809-815.
  • 2Willemese J L, Hendriks D F. Measurement of procar- boxypeptidase U (TAFI) in human plasma: a laboratory challengeEJ]. Clin Chem, 2006, 52(1):30-36.
  • 3Fidan E, Kavgaci H, Orem A, et al. Thrombin activat- able fibrinolysis inhibitor and thrombin-antithrombin-III- complex levels in patients with gastric cancerE Jl. Tumour Biol, 2012, 33(5) :1519-1525.
  • 4Eser M, Kement M, Balin S, et al. Is there any role of thrombin activatable fibrinolysis inhibitor in the develop- ment of a hypercoagulable state in gastric cancer ~ J ~. World J Surg Oncol, 2012, 10:180. doi: 10. 1186/1477- 7819-10-180.
  • 5Kovacova E, Kinova S, Duffs I, et al. General changes in hemostasis in gastric cancer ~ J ]. Bratisl Lek Listy, 2009, 110(4) :215-221.
  • 6Laporte S, Mismetti P, D6cousus H, et al. Clinical pre- dictors for fatal pulmonary embolism in 15,520 patients with venous thromboembolism: findings from the RegistroInformatizado de la Enfermedad TromboEmbolica venosa (RIETE) Registry E J]. Circulation, 2008, 117 ( 13 ) : 1711-1716.
  • 7Heit J A, O' Fallon W M, Petterson T M, et al. Relative impact of risk factors for deep vein thrombosis and pulmo- nary embolism: a population-based studyl J]. Arch Intern Med, 2002, 162(11) :1245-1248.
  • 8Lip G Y, Chin B S, Blann A D. Cancer and the pro- thrombotic stateEJ]. Lancet Oncol, 2002, 3(1 ) :27-34.
  • 9Varki A. Trousseau's syndrome: multiple definitions and multiple mechanisms E Jl. Blood, 2007, 1 l0 : 1723-1729.
  • 10Zwicker J I, Furie B C, thrombosis I J ]- Crit Rev (2) :126-136. Furie B. Cancer-associated Oncol Hematol, 2007, 62.

二级参考文献19

  • 1邵志敏,沈镇宙.21世纪乳腺癌治疗的展望[J].中国癌症杂志,2005,15(5):405-407. 被引量:29
  • 2张丽萍,董丽凤,张泰昌,夆徹哉.日本早期胃癌的诊断和治疗概况[J].北京医学,2006,28(11):684-686. 被引量:1
  • 3侯培锋,张祥福,郑知文.早期胃癌临床病理特点与外科治疗的远期疗效[J].中华胃肠外科杂志,2007,10(1):53-56. 被引量:19
  • 4Lee E, Chae Y, Kim I, et al. Prognostic relevance of immunohistochemically detected lymph node micrometastasis in patients with gastric carcinoma. Cancer, 2002, 94 ( 11 ) : 2867- 2873.
  • 5Abe N, Mori T, Takeuchi H, et al. Laparoseopic lymph node dissection after endoscopic submucosal dissection: a novel and minimally invasivc approach to treating early stage gastric cancer. Am J Surg, 2005, 190(3) :496-503.
  • 6Abe N, Watanabe T, Sugiyama M, et al. Endoscopic treatment or surgery for undifferentiated early gastric cancer? Am J Surg, 2004, 188(2) : 181-184.
  • 7Okabayashi T, Kobayashi M, Nishimori I, et al. Clinicopathological features and medical management of early gastric cancer. Am J Surg, 2008, 195(2):229-232.
  • 8Gotoda T. Endoscopic resection of early gastric cancer. Gastric Cancer, 2007, 10(1):1-11.
  • 9Boric F, Millat B, Fingerhut A, et al. Lymphatic involvement in early gastric cancer: prevalence and prognosis in France. Arch Surg, 2000, 135(10) : 1218-1223.
  • 10Kato M, Saji S, Kawaguchi Y, et al. A comparison of the prognostic significance between the number of metastatic lymph nodes and nodal stage in gastric carcinoma. Hepatogastroenterol, 1999, 46(30) : 3281-3286.

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同被引文献66

  • 1李云鹏,闫景全.胃癌患者凝血指标的变化及临床意义[J].中国医学工程,2011,19(2):99-99. 被引量:7
  • 2Loo LM, Tiirikainen M, Cheng I, et al. Integrated analysis of genome- wide copy number alterations and gene expression in microsatellite stable, CpG island methylator phenotype-negative colon Genes Chromosomes Cane 52(5):450-466. cancer[J] er. 2013.
  • 3Sheng J, Deng HW, Calhoun VD, et al. Integrated analysis of gene expression and copy number data on gene shaving using independent component analysis[J]. IEEE/ACM Trans Comput Biol Bioinform, 2011,8(6):1568-1579.
  • 4Atkinson JM, Pullen N, Da Silva-Lodge M, et al. Inhibition of thrombin-activated fibrinolysis inhibitor increases survival in experimental kidney fibrosis[J].JAm Soc Nephrol, 2015, 26(8):1925-1937.
  • 5Li Y, Zeng Z, Zhao J, et al. Association between polymorphisms in the flanking region of the TAFI gene and atherosclerotic cerebral infarction in a Chinese populationU]. Lipids Health Dis. 2014. 13:80.
  • 6Abdel Razeq H, Albadainah F, Hijjawi S, et al. Venous throm- boembolism(VTE) in hospitalized cancer patients: prophylaxis failure or failure to prophylax [ J ]. Thromb Thrombolysis, 2011, 31:107-112.
  • 7Thorson CM, Van Haren RM. Persistence of Hypercoagulable States after resection of intra-abdominal malignancy[ J]. J Amer- ican College Surgeons, 2013, 31:580-589.
  • 8. Piatek C, Liebman HA. Treating venous thromboembolism in patients with cancer [ J ] . Expert Rev Hematol, 2012, 5 : 201-209.
  • 9杨丽红,金艳慧,王明山.胃癌患者血小板和高凝状态有关参数的变化和意义[J].现代实用医学,2009,21(2):101-102. 被引量:2
  • 10王昌华,张红,刘柏,周彪.胃癌组织血液供应特点分析及意义[J].山东医药,2010,50(14):84-85. 被引量:4

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