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重组人促红细胞生成素后处理对肢体缺血再灌注诱发大鼠肾损伤的影响 被引量：1

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摘要 目的探讨重组人促红细胞生成素(rHu-EPO)后处理对肢体缺血再灌注(IR)诱发大鼠肾损伤的影响,以及核转录因子-κB亚基p65亲和肽(NF-κB p65)、TNF-α在其中的作用。方法选择健康成年雄性SD大鼠30只,随机分为假手术组、肢体IR组、rHu-EPO后处理组(rHu-EPO组)各10只。3组均于再灌注2 h后检测血清尿素氮(BUN)、肌酐(Cr),检测肾组织中的超氧化物歧化酶(SOD)活性、丙二醛(MDA)、TNF-α及NF-κB p65表达。结果与假手术组比较,肢体IR组、rHu-EPO组的血清BUN与Cr、肾组织中的MDA与TNF-α升高,SOD活性降低(P均<0.05);与肢体IR组比较,rHu-EPO组BUN、Cr降低,肾组织中的MDA、TNF-α降低,SOD活性升高(P均<0.05)。肢体IR组肾组织中的NF-κB p65阳性表达明显,rHu-EPO组的NF-κB p65阳性表达高于假手术组、但低于肢体IR组(P均<0.05)。结论 rHu-EPO可减少氧自由基、TNF-α生成,抑制NF-κB p65表达,对大鼠肢体IR诱发的肾损伤有保护作用。
作者 陆佳伟 缪惠东 顾红星 薛亚岗
机构地区 苏州大学附属张家港市第一人民医院
出处 《山东医药》 CAS 2014年第5期23-25,共3页 Shandong Medical Journal
关键词 肾损伤 缺血再灌注 重组人促红细胞生成素 核转录因子-κB亚基p65亲和肽 肿瘤坏死因子-α 大鼠
分类号 R692 [医药卫生—泌尿科学]
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参考文献15

  • 1Yassin MM,Harkin DW,Barros D. Lower limb ischcmlareperfusion injury triggers a systemic inflammatory response and multiple organ dysfunction[J].{H}WORLD Journal OF SURGERY,2002,(1):115-121.
  • 2Selimoglu O,Ugurlucan M,Basaran M. Eficacy of remote ischaemic preconditioning for spinal cord protection against ischaemic injury:association with heat shock protein expression[J].Folia Neuro-pathd,2008,(3):204-212.
  • 3Zhao JL,Fang Y J,Pei WD. Remote periconditioning reduces myoc ardial no-refiow by the activation of KATP channd via inhibition of Rho,kinase[J].{H}International Journal of Cardiology,2009,(2):179-184.
  • 4原标,王国忠,陈大志,高春锦.高压氧在大鼠肢体缺血再灌注致远隔多器官损伤中的作用[J].中华实验外科杂志,2006,23(12):1568-1568. 被引量：3
  • 5Morsey H,Aslam M,Standfield N. Patients with critical ischenia of the lower limb are at risk of developing kidney dysfunction[J].{H}AMERICAN JOURNAL OF SURGERY,2003,(4):360-363.
  • 6Pompermayer K,Souza DG,Lara GG. The ATP-sensitive potassium channel blocker glibenclamide prevents renal ischemia/reperfusion injury in rats[J].{H}Kidney International,2005,(5):1785-1796.
  • 7Guijarru C,Egido J. Transcription factor kappa B (NF kappa B)and renal disease[J].{H}Kidney International,2001,(2):415-424.
  • 8lshikawa H,Claudio E,Dambach D. Chronic inflammation andsusceptibility to bacterial infections in mice lacking the polypeptide (p) 105 precursor (NF-κB) but expressing p50[J].{H}Journal of Experimental Medicine,1998,(8):985-996.
  • 9Meldrum KK,Metcalfe P,Leslie JA. TNF-alpha neutralization decreases nuclear factor-kappaB activation and apoptosis during renal obstruction[J].Surg Res,2006,(2):182-188.
  • 10Omoya T,Shimizu I,Zhou Y. Efects of idoxifene and estradiol on NF-κB activation in cultured rat hepatocytes undergoing oxida2 tire stress[J].{H}LIVER,2001,(3):183-191.

二级参考文献17

共引文献7

同被引文献31

  • 1Masato Kato,Tokihiko Sawada,Junji Kita,Mitsugi Shimoda,Keiichi Kubota.Erythropoietin ameliorates early ischemia-reperfusion injury following the Pringle maneuver[J].World Journal of Gastroenterology,2010,16(38):4838-4845. 被引量：11
  • 2Yasuo Ishii, Tokihiko Sawada, Torn Murakami et al. Renoprotective effect of erythropoie- tin against ischaemia - reperfusion injury in a non - human primate model [ J ]. Nephrol Dial Transplant ,2011,26 : 1157 - 1162.
  • 3A. M. M. Caetano,P. T. G. Vianna Filho,Y. M. M. Castiglia et al. Erythropoietin Attenu- ates Apoptosis After Ischemia - Reperfusion - Induced Renal Injury in Transiently Hyper- glycemic Wister Rats[ J]. Transplantation Proceedings,2011,43:3618 -3621.
  • 4Manabu T. Moriyama,Tatsuro Tanaka, Nobuyo Morita et al. Renal Protecti Effects of Erythropoietin on Ischemic Reperfusion lnjury [ J ]. Cell Transplantation, 2010, 19 : 713 - 721.
  • 5Mohammad Reza Ardalan, Rasoul Estakbri, Babak Hajipour et al. Erythropzietin Amel- iorates Oxidative Stress and Tissue Injury following Renal Ischemia/Repeffusion in Rat Kidney and Lung[ J ]. Med Prine Pratt ,2013,22:70 - 74.
  • 6Willem G van Rijt, Gertrude J Nieuwenhuijs - Moekc, Harry van Goor et al. Renoprotec- tive capacities of non - erythropoietic EPO derivative, ARA290, following rend ischemia/ reperfusion injury [ J ]. Journal of Translational Medicine,20I 3,11:286.
  • 7Shigeyoshi Oba, Etsu Suzuki, Hiroaki Nishimatsu et al. Renoprotective effect of erytbro- poietin in ischemia/reperfusion injury: Possible roles of the Akt/endothelial nitric oxide synthase - dependent pathway [ J ]. International Journal of Urology, 2012,19 : 248 - 255.
  • 8Min XIONG, Sen CHEN, Hualong YU et al. Neumprotection of Erythmpoietin and Methylprednisolone against Spinal Cord Ischemia -Reperfusian Injury[ J ]. Hu hong Univ Sci Technol,2011,31 (5) :652 -656.
  • 9Florian Simon, Angelika Scheuerle, Michael Ginger et al. Comparison of carbamylated erythmpoietin- FC fusion protein and recombinant human erythropoietin duAng porcine aortic ballon occlusion - induced spinal cord ischemia/reperfusion injury [ J ]. Intensive Care Med,2011,37:1525 - 1533.
  • 10Heba M. Shawky, Sandra M. Younan, Leila A. Rashed et al. Effect of ecombinant erythropoietin on isehemia -reperfusion -induced apoptosis in rat liver[ J ]. Physiol Bio- chem.2012.68 : 19 - 28.

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山东医药
2014年 第5期

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