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miR-200c在肿瘤发生发展中的研究进展 被引量：4

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摘要 MicroRNA（缩写为miRNA或miR）是一类新发现的非编码单链RNA,由约22个核苷酸组成.它们广泛存在于动植物的真核细胞中,主要通过降解靶mRNA或者抑制其翻译,从而调节细胞分化、增殖和凋亡,参与胚胎发育、机体代谢和肿瘤发生发展等过程.越来越多的证据证明miRNA在不同肿瘤组织间存在异常表达,而且miRNA的表达与肿瘤的发生、发展、转移和预后等有关.miR-200c作为miR-200家族中重要成员之一,主要调控上皮间质转化（epithelial mesenchymal transition,EMT）过程,在多数肿瘤的发生及转移过程中发挥重要的作用.
作者 朱名毅 姚金光 刘津
机构地区 右江民族医学院
出处 《右江民族医学院学报》 2014年第1期80-82,共3页 Journal of Youjiang Medical University for Nationalities
基金 右江民族医学院科研项目(编号:右医科字[2011]1号)
关键词 MIR-200C 肿瘤
分类号 R730.2 [医药卫生—肿瘤]
  • 相关文献

参考文献24

  • 1Uhlmann S,Zhang JD,Schwager A. miR-200bc/429 cluster targets PLCgamma1 and differentially regulates proliferation and EGF-driven invasion than miR-200a/141 in breast cancer[J].{H}ONCOGENE,2010,(30):4297-4306.
  • 2Wiklund ED,Bramsen JB,Hulf T. Coordinated epigenetic repression of the miR-200 family and miR-205 in invasive bladder cancer[J].{H}International Journal of Cancer,2011,(06):1327-1334.
  • 3Chang CJ,Chao CH,Xia W. p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs[J].{H}Nature Cell Biology,2011,(03):317-323.
  • 4Zhang Y,Yang Z,Whitby R. Regulation of miR-200c by nuclear receptors PPARalpha,LRH-1 and SHP[J].{H}Biochemical and Biophysical Research Communications,2011,(1-2):135-139.
  • 5Magenta A,Cencioni C,Fasanaro P. miR-200c is upregulated by oxidative stress and induces endothelial cell apoptosis and senescence via ZEB1 inhibition[J].{H}Cell Death and Differentiation,2011,(10):1628-1639.
  • 6Burk U,Schubert J,Wellner U. A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells[J].{H}EMBO Reports,2008,(06):582-589.
  • 7Yu J,Ohuchida K,Mizumoto K. MicroRNA,hsa-miR-200c,is an independent prognostic factor in pancreatic cancer and its upregulation inhibits pancreatic cancer invasion but increases cell proliferation[J].{H}Molecular Cancer Therapautics,2010.169.
  • 8齐天伟,王罗,王光锁,孙学峰,王正.食管鳞癌中微小RNA miR-200c的表达及其意义[J].中国现代医学杂志,2012,22(19):42-45. 被引量：6
  • 9Xi Y,Formentini A,Chien M. Prognostic Values of microRNAs in Colorectal Cancer[J].Biomark Insights,2006.113-121.
  • 10张鹏,周总光,王玲,王默进,张益,崔长富,詹兰.直肠癌组织中miR-155和miR-200c的表达差异及意义[J].中华实验外科杂志,2010,27(1):59-61. 被引量：4

二级参考文献77

  • 1葛崇华,李庭芳.外阴癌病因的研究进展[J].国外医学（妇产科学分册）,2005,32(2):116-118. 被引量：8
  • 2孙凯,黄晓卉,甄茂川,汪谦.应用液相芯片分析肝细胞癌及癌旁组织小分子RNA表达谱差异[J].中华实验外科杂志,2006,23(8):945-947. 被引量：25
  • 3Grishok A, Pasquinelli AE, Conte D, et al. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing [J]. Cell, 2001, 106(1): 23-34.
  • 4Ambros V. MicroRNA pathways in flies and worms: growth, death, fat,stress ,and timing[J]. Cell, 2003, 113(6): 673-6.
  • 5Carrington JC, Ambros V. Role of microRNAs in plant and animal development[J]. Science, 2003, 301(5631): 336-8.
  • 6Calin GA, Dumitru CD, Shimizu M, et al.Frequent deletions and down-regulation ofmicro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia [J]. Proc Natl Acad Sci USA, 2002, 99(24): 15524-9.
  • 7Cimmino A, Calin GA, Fabbri M, et al. miR-15 and miR-16 induce apoptosis by targeting BCL2 [J]. Proc Natl Acad Sci USA, 2005, 102(39): 13944-9.
  • 8Yanaihara N, Caplen N, Bowman E, et al. Unique microRNA molecular profiles in lung cancer diagnosis and prognosis [J].Cancer Cell, 2006, 9(3): 189-98.
  • 9Kovalchuk O, Tryndyak YP, Montgomery B, et al. Estrogen-induced rat breast carcinogenesis is characterized by alterations in DNA methylation, histone modifications and aberrant microRNA expression[J]. Cell Cycle, 2007, 6(16): 2010-8.
  • 10Tavazoie SF, Alarcon C, Oskarsson T, et al. Endogenous human microRNAs that suppress breast cancer metastasis [ J ]. Nature, 2008, 451(7175): 147-52.

共引文献47

同被引文献41

  • 1谭国斌,邱明宁,陈合格,柳建军.miR-200c与肿瘤进展关系的研究进展[J].中国肿瘤生物治疗杂志,2015,22(1):120-124. 被引量：3
  • 2Okamura K, Ladewig E, Zhou L, et al. Functional small RNAs are generated from select miRNA hairpin loops in flies and mammals[J]. Genes Dev,2013,27(7) :778-792.
  • 3P6rez-Saydns M, Pilar GD, Barros-AngueiraF, et al. Cur- rent trends in miRNAs and their relationship with oral squamous cell carcinoma[J]. J Oral Pathol Med, 2012,41 (6) :433-443.
  • 4Endo H, Muramatsu T, Furuta M, et al. Potential of tumor- suppressive miR-596 targeting LGALS3BP as a therapeutic agent in oral cancer E J :. Carcinogenesis, 2013,34 ( 3 ) : 560- 569.
  • 5Jurmeister S,Baumann M,Balwierz A, et al. MicroRNA- 200c represses migration and invasion of breast cancer cells by targeting actin-regulatory proteins FHOD1 and PPMIF[J]. Mol Cell Bio,2012,32(3):633-651.
  • 6Davalos V, Moutinho C, Villanueva A, et al. Dynamic epi- genetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumori- genesis[J]. Oncogene, 2012,31 (16) : 2062-2074.
  • 7Zhang Z,Liu ZB,Ren WM,et al. The miR-200 family reg- ulates the epithelial- mesenchymal transition induced by EGF/EGFR in anapIastic thyroid cancer cells[J]. Int J Mol Med,2012,30(4) :856-862.
  • 8Jia LF, Wei SB, Gong K, et al. Prognostic implications of micoRNA miR-195 expression in human tongue squamous cell carcinoma[J]. PLoS One,2013,8(2) :e56634.
  • 9Feng X, Wang Z, Fillmore R, et al. MiR-200, a new star miRNA in human cancer[J]. Cancer Lett, 2014,344 (2) : 166-173.
  • 10Czabotar PE, Lessene G, Strasser A, et al. Control of ap- optosis by the BCL-2 protein family: implications for physiology and therapy[J]. Nat Rev Mol Cell Biol, 2014, 15(1) :49-63.

引证文献4

二级引证文献12

右江民族医学院学报
2014年 第1期

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