摘要
目的 探讨妊娠期妇女亚临床甲状腺功能减退（简称亚临床甲减）对后代智力发育的影响.方法 计算机检索关于妊娠期妇女亚临床甲减对后代智力发育影响的随机对照研究.在严格质量评价的基础上,应用RevMan 5.1软件进行Meta分析.结果 纳入的文献共8篇,包含731个研究对象.Meta分析结果显示,妊娠期妇女亚临床甲减对后代智力发育的影响与对照组相比差异有统计学意义（P＜0.05）;妊娠期妇女亚临床甲减经左旋甲状腺素（LT4）干预后对后代智力发育的影响与对照组比较,差异无统计学意义（P＞0.05）.结论 妊娠期妇女亚临床甲减对后代的智力发育会造成不良影响,经积极治疗后可减小这种危害.
Objective To evaluate the impact on the mental development of the offspring by pregnant women with subclinical hypothyroidism. Methods Computer retrieve the random control studys about the impact on the mental development of the offspring by pregnant women with subclinical hypothy- roidism. Data analyses were performed with the RevMan 5.1 software, based on the strict quality evalua- tion. Results Eight studies comprising 731 subjects were analyzed. Meta-analyses showed that the impact on the mental development of the offspring by pregnant women with subclinical hypothyroidism had statisti- cal significance, when compared with the control group （P 〈 0.05 ）. The impact on the mental development of the offspring by pregnant women with subclinical hypothyroidism treated with LT4 had no significance, when compared with the control group （ P 〉 0. 05 ）. Conclusion Gestational women with subclinical hypothyroidism will adversely affect the mental development of future generations, but the harm can be reduced after active treatment.
出处
《临床内科杂志》
CAS
2014年第1期46-48,共3页
Journal of Clinical Internal Medicine
关键词
妊娠期
亚临床甲减
后代智力发育
LT4干预
META分析
Pregnancy
Subclinical hypothyroidism
Offspring mental development
LT4 treated
Meta-analysis
