摘要
目的观察阿维A治疗寻常性银屑病的疗效及安全性。方法将入选的84例寻常性银屑病患者随机分为两组,各42例。治疗组予阿维A胶囊口服,对照组予消银片口服,对两组患者分别于治疗前及治疗第6周时进行银屑病面积和严重程度指数(PASI)评分,比较两组患者的临床疗效和不良反应情况。结果治疗第6周时治疗组有效率为92.86%,对照组为73.81%,差异有统计学意义(P<0.05)。用药过程中监测不良反应:治疗组有血甘油三酯升高,轻度口干、皮肤干燥;对照组有轻微腹泻。结论口服阿维A治疗寻常性银屑病的疗效好,安全性高。
Objective To observe the efficacy and safety of acitretin for psoriasis vulgaris. Methods Eighty-four cases with psoriasis vulgaris were randomly divided into two groups. Forty-two cases（ treatment group） were treated with acitretin capsules orally, and the other 42 cases were treated by Xiaoyin tablets, respectively. After 6 weeks,Psoriasis Area and Severity Index （PASI） score and adverse reactions were recorded. Results The efficacy of treatment after 6 weeks were 92.86% and 73.81% respectively in the treatment and control group, showing significant difference （ P 〈 0.05 ）. Elevated blood triglycerides, mild dry mouth, dry skin were observed in treatment group,andmild diarrhea occurred in the controls. Conclusion Oral acitretin treatment for psoriasis vulgaris is effective and safe.
出处
《中国皮肤性病学杂志》
CAS
北大核心
2014年第3期327-328,共2页
The Chinese Journal of Dermatovenereology
关键词
阿维A
消银片
银屑病
寻常性
Acitretin
Xiaoyin tablets
Psoriasis vulgaris
