固有免疫系统Toll-Like受体和炎性小体在炎症及衰老中的作用
摘要
Toll样受体(Toll-1ike receptors,TLRs)作为固有免疫系统受体之一,在启动和调节天然免疫及诱导获得性免疫中发挥重要作用。炎性小体也是固有免疫的重要组分,能被多种类型的病原体或危险信号所激活,在机体免疫反应和疾病发生过程中具有重要作用。
出处
《实用老年医学》
CAS
2014年第2期104-107,共4页
Practical Geriatrics
基金
国家973计划项目(2011CBA01003
2011CB964904)
参考文献20
-
1Cai W, He JC, Zhu L, et al. Oral glycotoxins determine the effects ofcalorie restriction on oxidant stress, age-related diseases, and lifespan [J]. Am J Pathol, 2008, 173(2) : 327-336.
-
2Martinon F, Burns K, Tschopp J. The inflammasome: a molecular plat- form triggering activation of inflam- matory caspases and processing of proIL-beta [ J]. Molec Cell, 2002, 10(2) : 417-426.
-
3Song Y, Shen H, Schenten D, et al. Aging enhances the basal production of IL-6 and CCL2 in vascular smooth muscle cells [ J ]. Arterioscler Thromb Vasc Biol, 2012, 32 (1) : 103-109.
-
4Shirali AC, Goldstein DR. Tracking the toll of kidney disease [ J ]. J Am Soci Nephrol, 2008, 19 ( 8 ): 1444-1450.
-
5Van Duin D, Mohanty S, Thomas V, et al. Age-associated defect in human TLR-1/2 function [ J ]. J Im- munol, 2007, 178(2): 970-975.
-
6Van Duin D, Shaw AC. Toll-like re- ceptors in older adults [ J ]. J Am Geria Soci, 2007, 55 ( 9 ): 1438-1444.
-
7Shaw AC, Panda A, Joshi SR, et al. Dysregulation of human Toll-like re- ceptor function in aging [ J ]. Ageing Res Rev, 2011, 10(3) : 346-353.
-
8Panda A, Qian F, Mohanty S, et al.Age-associated decrease in TLR -function in primary human dendritic cells predicts influenza vaccine re- sponse [J]. J Immuol, 2010, 184 (5) : 2518-2527.
-
9Asquith M, Haberthur K, Brown M, et al. Age-dependent changes in innate immune phenotype and function in rhesus macaques ( Macaca mulatta) [ J ]. Pathobiol Aging Age Relat Dis, 2012, Epub 2012 Jun 15.
-
10Lutz CT, Quinn LS. Sarcopenia, o- besity, and natural killer cell immune senescence in aging: altered cytokine levels as a common mecha- nism [J]. Aging, 2012, 4(8): 535-546.
二级参考文献156
-
1Rashu B Seth Lijun Sun Zhijian J Chen.Antiviral innate immunity pathways[J].Cell Research,2006,16(2):141-147. 被引量:49
-
2李守新,黄睿,徐咏芬,王晓慧,刘雯,雷小妹.系统性红斑狼疮外周血B淋巴细胞激活及TOLL样受体9表达[J].中华风湿病学杂志,2006,10(2):82-84. 被引量:10
-
3Ichinohe T, Lee HK, Ogura Y, Flavell R, lwasaki A. Inflammasome recognition of influenza virus is essential for adaptive immune responses. J Exp Med 2009; 206(1): 79-87.
-
4Kanneganti TD, Body-Malapel M, Amer A, Park JH, Whitfield J, Franchi L, et al. Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA. J Biol Chem 2006; 281(48): 36560-8.
-
5Muruve DA, Petrilli V, Zaiss AK, White LR, Clark SA, Ross P J, et al. The inftammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response. Nature 2008; 452(7183): 103-7.
-
6Di Paolo NC, Miao EA, Iwakura Y, Murali-Krishna K, Aderem A, Flavell RA, et al. Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo. Immunity 2009; 31 (1): 110-21.
-
7Barlan AU, Griffin TM, McGuire KA, Wiethoff CM. Adenovirus membrane penetration activates the NLRP3 inflammasome. J Viro12011; 85(1): 146-55.
-
8Rajan JV, Rodriguez D, Miao EA, Aderem A. The NLRP3 inflammasome detects encephalomyocarditis virus and vesicular stomatitis virus infection. J Viro12011; 85(9): 4167-72.
-
9Poeck H, Bscheider M, Gross O, Finger K, Roth S, Rebsamen M, et aL Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production. Nat Immuno12010; 11 (1): 63-9.
-
10Hornung V, Ablasser A, Charrel-Dennis M, Bauernfeind F, Horvath G, Caffrey DR, et al. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 2009; 458(7237): 514-8.
共引文献33
-
1阎双缓,陈翠英,王素平,唐亚芳,宋海燕,耿建章,王晓静,高朋彬.乙型肝炎肝硬化患者外周血单个核细胞Toll样受体4的变化[J].实用肝脏病杂志,2012,15(5):447-448. 被引量:2
-
2阎双缓,曹志宸.干扰素治疗前后慢性乙型肝炎患者外周血单核细胞Toll样受体4的变化[J].河北医科大学学报,2012,33(10):1173-1175.
-
3方潮,王中新,胡元生,袁媛,石杜娟.弓形虫感染与NLRP3炎症小体相关性的初步研究[J].安徽医科大学学报,2012,47(12):1381-1384. 被引量:3
-
4张玲,杨彩梅,曹广添,肖英平,曾新福.Toll样受体与益生菌免疫[J].动物营养学报,2013,25(1):21-25. 被引量:5
-
5李彤,张娟,张桂珍,徐江涛,张萍,蒋俊,孙秀华,杜珍武.TLR8基因多态性与中国东北地区汉族肺结核病的关联性分析[J].吉林大学学报(医学版),2013,39(3):584-587. 被引量:1
-
6胡庆华,缪明星,卢国,季晖.槲皮素对尿酸性肾病大鼠肾脏NLRP3和TLRs表达的影响[J].中草药,2013,44(24):3496-3502. 被引量:19
-
7冯媛媛,白雪源,陈香美.Toll样受体在糖尿病肾病发病中的作用[J].医学综述,2014,20(4):594-596. 被引量:7
-
8张丽萍,帕丽达.阿布力孜.炎症小体在真菌感染中的作用机理研究进展[J].中国美容医学,2014,23(11):941-945. 被引量:1
-
9王晓彤,韩涛.NLRP3炎症小体在肝脏疾病发病中的作用研究进展[J].实用肝脏病杂志,2014,17(5):546-549. 被引量:2
-
10孙超,李志军.Toll样受体4与干燥综合征研究进展[J].中国现代医生,2015,53(8):153-156.
-
1李倩,王成,徐文岳.病原菌和宿主遗传背景在败血症发生中的作用和机制研究进展[J].免疫学杂志,2010,26(10):906-908. 被引量:3
-
2牟慧,蔡辉.Toll-like受体在类风湿关节炎中的作用机制研究进展[J].临床内科杂志,2013,30(1):70-71. 被引量:1
-
3仉红刚.Toll-like受体在血管内皮细胞损伤中的作用[J].国外医学(临床生物化学与检验学分册),2003,24(3):127-128. 被引量:2
-
4杜军辉,李蓉,马楼艳,侯鹏飞.自噬与炎症的关系及其在眼科疾病中的相关研究进展[J].临床眼科杂志,2017,25(1):91-94. 被引量:2
-
5刘幸卉,张任飞,史丹丹,曹标,术蓉,谷瑞彩,肖将尉,廖华.NO抑制体外IFN-γ刺激成肌细胞/肌管NLRP3炎性小体活化[J].基础医学与临床,2016,36(3):331-336. 被引量:1
-
6葛安兴,褚旭芳,文日,傅方洁,王雪莲.发热样温度对朗格汉斯细胞表面抗原递呈相关分子及Toll-like受体表达的影响[J].中国病原生物学杂志,2015,10(6):491-494. 被引量:3
-
7杨宜英.病毒感染时NLRP3炎性小体激活和调控机制研究进展[J].中山大学研究生学刊(自然科学与医学版),2014,35(3):6-12. 被引量:1
-
8朱琳,赵晓航.炎性小体研究进展[J].生命科学,2014,26(7):709-716. 被引量:7
-
9刘元,郭俊峰,蔡俊,杨阳,李鑫,张慧宇,张纲.降钙素基因相关肽通过降低炎性小体活性抑制巨噬细胞功能[J].免疫学杂志,2017,33(5):400-404. 被引量:8
-
10任大宾,杜烨玮,张健,孙仁宇,王士雯.静脉注射脂多糖上调小鼠肺及肝CD14和Toll-like受体4表达[J].基础医学与临床,2005,25(4):331-336. 被引量:12