期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

静息状态下未服药首发重性抑郁症患者杏仁核功能连接的研究 被引量：7

The Study on Functional Connectivity of Amygdala in First-episode Medication-naive Major Depressive Disorder During Resting-state
原文传递
导出
摘要 目的:采用静息态功能磁共振技术,探讨静息状态下未服药首发重性抑郁症患者杏仁核功能连接的异常改变。方法:对32例未服药首发重性抑郁症患者及35例健康对照者进行静息态功能磁共振成像扫描。以双侧杏儿核为感兴趣区,分别进行静息态脑功能连接分析。结果:与健康对照组相比,首发重性抑郁症患者左侧杏仁核与左侧眶额皮层的功能连接显著减弱。结论:情感网络中眶额皮层-杏仁核功能连接的异常可能是重性抑郁症的一个重要神经病理机制。 Objective： Using resting-state functional magnetic resonance imaging technique, to study the functional con- nectivity of amygdale in first-episode, medication-naive patients with major depressive Disorder（MDD） during resting- state. Methords： Resting-state functional magnetic resonance imaging scans were performed in 32 first-episode, medica- tion-naive patients with MDD and 35 matched healthy controls（HC）. The resting-state functional connectivity was investi- gated using bilateral amygdala as seed regions. Results： Compared to HC, MDD patients showed reduced functional con- nectivity during resting-state between left amygdale and left orbitofrontal cortex（OFC）. Conclusion： In the affective net- work, abnormal functional connectivity between the amygdala and OFC may represent the important neuropathological mechanisms of MDD.
作者 张小崔 雷辉 朱雪玲 朱熊兆 姚树桥
机构地区 中南大学湘雅二医院医学心理学研究所 国防科学技术大学人文与社会科学学院
出处 《中国临床心理学杂志》 CSSCI CSCD 北大核心 2014年第1期16-18,11,共4页 Chinese Journal of Clinical Psychology
基金 湖南省研究生科研创新项目(CX2011B068) 国家自然科学基金项目(81071104 30670709)
关键词 抑郁症 杏仁核 眶额皮层 磁共振成像 Depression Amygdala Orbitofrontal cortex Magnetic Resonance Imaging（MRI）
分类号 R395.1 [医药卫生—医学心理学]
  • 相关文献

参考文献20

  • 1American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th ed., text Revision(DSM-IV-TR). Washington DC, 2000.
  • 2Beauregard M, Paquette V, L6vesque J. Dysfunction in the neural circuitry of emotional self-regulation in major depre- ssive disorder. Neuroreport, 2006, 17(8): 843-846.
  • 3张小崔,廖坚,朱雪玲,肖晶,姚树桥.抑郁症认知易感者杏仁核体积的研究[J].中国临床心理学杂志,2011,19(1):10-13. 被引量：10
  • 4Frodl T, Meisenzahl E, Zetzsche T, et al. Enlargement of the amygdala in patients with a first episode of major depression. Biological Psychiatry, 2002, 51 (9): 708-714.
  • 5Victor TA, Furey ML, Fromm SJ, et al. Relationship between amygdala responses to masked faces and mood state and tre- atment in major depressive disorder. Archives of General Psychiatry, 2010, 67(11): 1128-1138.
  • 6Mingtian Z, Shuqiao Y, Xiongzhao Z, et al. Elevated amygd- ale activity to negative faces in young adults with early onset major depressive disorder. Psychiatry Research: Neuroimag- ing, 2012, 201(2):107-112.
  • 7Lee BT, Seok JH, Lee BC, et al. Neural correlates of affect- ive processing in response to sad and angry facial stimuli in patients with major depressive disorder. Progress in Neuro- psychopharmacol and Biological Psychiatry, 2008, 32(3): 778-785.
  • 8Ghashghaei HT, Hilgetag CC, Barbas H. Sequence of infor- mation processing for emotions based on the anatomic dia- logue between prefrontal cortex and amygdala. Neuroimage, 2007, 34(3): 905-923.
  • 9Fitzgerald PB, Laird AR, Mailer J, et al. A meta-analytic study of changes in brain activation in depression. Human Brain Mapping, 2008, 29(6): 683-695.
  • 10Drevets WC, Price JL, Furey ML. Brain structural and func- tional abnormalities in mood disorders: Implications for neu- rocircuitry models of depression. Brain Structure and Func- tion, 2008. 213(1-2): 93-118.

二级参考文献24

  • 1Giedd JN, Castellanos FX, Rajapakse JC, et al. Sexual dimorphism of the developing human brain. Biological Psychiatry, 1997, 21:1156-1201.
  • 2Beauregard M, Paquette V, Le vesque J. Dysfunction in the neural circ, uitry of emotional self-regulation in major depressive disorder. Neuroreport, 2006, 17:843:-846.
  • 3Frodl T, Meisenzahl E, Zetzsche T, et al. Enlargement of the amygdala in patients with a ?rst episode of major depres- sion. Biol Psychiatry, 2002, 51:708-714.
  • 4Ingrain RE, Laxton DD. Vulnerability stress models. In: Hankin BL, Abela JRZ. Development of psychopathology: A vulnerability-stress perspective. NewYork, 2005. 32-46.
  • 5Abela JRZ, Satin S. Cognitive vulnerability to hopelessness depression: A chain is only as strong as its weakest link. Cognitive Therapy and Research, 2002, 26:811-829.
  • 6Abela JRZ. Depressive mood reactions to failure in the achievement domain: A test of the integration of the hopelessness theory and selfesteem theories of depression. Cognitive Therapy and Research, 2002. 26:531-552.
  • 7Alloy LB, Abramson LY, Hogan ME, et al. The Temple-Wisconsin cognitive vulnerability to depression project: Lifetime history of axis-1 psychopathology in individuals at high and low cognitive risk for depression. Journal of Abnormal Psychology, 2000, 109:403-418.
  • 8Radloff LS. The CES-D scale: A self-report depression scale for research in the general population. Applied Psychological Measurement, 1977, 1:385-401.
  • 9Tamraz JC, Comair YG. Atlas of regional anatomy of the brain using MRI with functional eorrelations. Berlin: Springer-Verlag,2000. 168-181.
  • 10Watson C, Andermann F, Gloor P, et al. Anatomic basis of amygdaloid and hippocampal volume measurement by magnetic resonance imaging. Neurology, 1992, 42:1743-1750.

共引文献9

同被引文献129

  • 1赵小虎,王培军,揭兵,席芊,甘露,雷涛.高血压患者临床前认知损害的功能磁共振评价[J].中华医学杂志,2007,87(3):170-173. 被引量：4
  • 2Kessler RC, Berglund P, Demler O, et al. The epidemiology of major depressive disorder: Results from the national eom- orbidity survey replication. JAMA, 2003, 289(23): 3095- 3105.
  • 3Beck AT. Depression: Clinical, experimental, and theoreti- cal aqspects. Harper and Row, New York, 1996.
  • 4Gotlib IH, Krasnoperova E, Yue DN, et al. Attentional bias- es for negative interpersonal stimuli in clinical depression. J Abnorm Psychol, 2004, 113:121-135.
  • 5Hasler G, Drevets WC, Manji HK, et al. Discovering endo- phenotypes for major depression. Neuropsychopharmacolo- gy, 2004, 29:1765-1781.
  • 6Corbetta M, et al. A common network of functional areas for attention and eye movements. Neuron, 1998, 21:761-773.
  • 7Beevers CG, Clasen P, Stice E, et al. Depression symptoms and cognitive control of emotion cues: a functional magnetic resonance imaging study. Neuroscience, 2010, 167:97-103.
  • 8Zhong M, Zhu X, Yi J, et al. Do the early attentional compo- nents of ERPs reflect attentional bias in depression? It de- pends on the stimulus presentation time. Clinical Neurophy- siology, 2011, 122:1371-1381.
  • 9Gotlib IH, Hamilton JP. Neuroimaging and depression: Cur- rent status and unresolved issues. Curt Dir Psychol Sci, 2008, 17:159-163.
  • 10Bush G, Luu P, Posner MI. Cognitive and emotional influen- ces in anterior cingulate cortex. Trends Cogn Sci, 2000, 4: 215-222.

引证文献7

二级引证文献81

中国临床心理学杂志
2014年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部