摘要
采用挤压法制备了海藻酸钠/羽毛蛋白(SA/FK)复合微球。用FTIR和黏度法研究了SA/FK体系的交互作用、探讨了不同制备条件(FK用量、交联剂质量分数、交联时间)、溶胀溶液性质(pH、温度、离子强度)对溶胀性能的影响。结果表明,复合体系的交互作用是静电为主,氢键次之。随着时间延长,溶胀速率变缓,最终达到溶胀平衡。当m(FK)/m(SA)=0.60、w(CaCl2)=7%、交联时间为60 min时,复合微球网络结构最紧密,溶胀速率最低,平衡溶胀率分别为0.6、0.6、0.9。pH由1增加至7,平衡溶胀率仅从0.9升至1.1,当pH=13时,平衡溶胀率升至3.8。温度由30℃提高至45℃,平衡溶胀率从0.6升至0.9。离子强度由0增加至0.6 mol/L,平衡溶胀率从1.1升至13.8。SA/FK复合微球具有pH/温度/离子强度敏感性,有望实现新型智能缓释微球的开发。
Sodium alginate/feather keratin（SA/FK） microspheres were prepared by extrusion dripping method. The interactions of SA and FK were characterized by means of FTIR and viscosimetry. The effects of preparation conditions [ m （ FK ）/m （ SA ）, w （ CaC12 ）, crosslinking time ~ and solution properties （pH, temperature, ionic strength ）, on the swelling ratio were also investigated. The results indicate that electrostatic interaction is the main interaction, which is followed by hydrogen bond interaction. Over time, the swelling rate becomes slow, and it meets equilibrium swelling at last. SA/FK microspheres have compact network structures when m （FK）/m （SA） = 0.60, w （ GaG12 ） = 7% and crosslinking time is 60 rain. The equilibrium swelling ratios are 0. 6,0.6, and 0.9. The equilibrium swelling ratio rises from 0. 6 to 0. 9 when the temperature rises from 30 % to 45 ~C. The equilibrium swelling ratio rises from 0. 9 to 1.1 when pH rises from 1 to 7. When pH = 13, it rises to 3.8. The equilibrium swelling ratio rises from 1.1 to 13.8 when ionic strength increases from 0 to 0.6 moL/L. SA/FK microspheres possess the ionic strength/temperature/pH sensitivity, which holds out hope for the development of new intelligent slow-release microspheres.
出处
《精细化工》
EI
CAS
CSCD
北大核心
2014年第3期312-316,353,共6页
Fine Chemicals
基金
国家自然科学基金(21176269)
广东省自然科学基金(S2012010008979)~~
关键词
海藻酸钠
羽毛蛋白
智能微球
交互作用
溶胀性能
功能材料
sodium alginate
feather keratin
intelligent microspheres
interactions
swelling properties
functional materials
