摘要
目的 探讨胸腔内注入顺铂 (DDP)联合长春地辛 (VDS)治疗恶性胸腔积液的疗效。方法 病理确诊的恶性胸腔积液 6 0例 ,经胸腔插管引流术排尽胸液后 ,按随机化原则分为 2组 ,治疗组(32例 )在胸腔内注入DDP 40mg/m2 ,VDS 4mg ,对照组 (2 8例 )在胸腔内注入DDP 40mg/m2 ,1周后重复 1次 ,观察疗效、生活质量、生存率以及毒副反应。结果 治疗组总有效率 81% ,病变进展率 3% ,较对照组 5 0 % ,2 5 %差异有显著性 (P <0 0 5 )。Karnofsky评分大于 70分治疗组较对照组有显著提高(P <0 0 5 )。治疗组 0 5年、1年、1 5年、2年的生存率为 97%、5 9%、44 %、6 % ,分别高于对照组的71%、5 0 %、14%、4% ,其中 0 5 ,1 5年的生存率差异有显著性 (P <0 0 5 )。治疗组Ⅰ度白细胞下降较对照组明显。结论 胸腔内联合注入DDP和VDS治疗恶性胸腔积液是一种有效的、副反应小。
Objective To evaluate the efficacy of treating malignant pleural effusion with cisplatine and vindesine by injection through thoracic tube intubation. Methods 60 cases with malignant pleural effusion,after drainage,vindesine 4 mg,cisplatine 40 mg/m 2 were injectred into pleural cavity in therapy group(T),and only cisplatine 40 mg/m 2 in control group (C) the tretment was repeated after a week,then evaluate the efficacy,survival rate,toxicities and quality of life. Results The response rate was 81% in T group and 50% in C group There was statistical difference in two groups ( P <0 05) The Karnofsky score is higher in T group than in C group The half year,one year,one and half year,two year survival rates were 97%,59%,44%,6% in T group and 71%,50%,14%,4% in C group Grade I leukopenia is higher in T group than in C group. Conclusion The treatment to use Vindesine and cisplatine through thoracic tube is regarded as effective,slight side effect and welltolerated method for malignant pleural effusion
出处
《中华结核和呼吸杂志》
CAS
CSCD
北大核心
2001年第1期29-31,共3页
Chinese Journal of Tuberculosis and Respiratory Diseases
